The etiology of bipolar disorder (BD) is still poorly understood, involving genetic and
epigenetic mechanisms as well as environmental contributions. This study aimed to …

Background The brain derived neurotrophic factor (BDNF) gene and its epigenetic
regulation have been repeatedly implicated in the pathophysiology of mood disorders …

To the Editor: Major depressive disorder (MDD) and bipolar disorder (BD) are prevalent and
disabling mood disorders, characterized by recurring mood fluctuations over the life span …

Background Alterations of brain-derived neurotrophic factor (BDNF) DNA methylation at
specific BDNF promoters and corresponding gene expressions are associated with …

Preliminary evidence suggests that BDNF (brain derived neurotrophic factor) rs6265 genetic
polymorphism, BDNF gene promotor methylation and BDNF serum levels might play an …

Accumulating evidence suggests that epigenetic alterations in brain-derived neurotrophic
factor (BDNF) promoters are associated with the pathophysiology of psychiatric disorders …

Background The importance of epigenetic alterations in psychiatric disorders is increasingly
acknowledged and the use of DNA methylation patterns as markers of disease is a topic of …

Bipolar disorder (BD) is a multifactorial illness thought to result from an interaction between
genetic susceptibility and environmental stimuli. Epigenetic mechanisms, including DNA …

Insufficient response to antidepressant pharmacotherapy with monoaminergic drugs is a
major problem in the therapy of major depression (MD), occurring in up to two-thirds of …

Downregulation of brain-derived neurotrophic factor (BDNF) gene expression with
corresponding increased methylation at specific promoters has been associated with …