Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

MA Nalls, C Blauwendraat, CL Vallerga… - The Lancet …, 2019 - thelancet.com
Background Genome-wide association studies (GWAS) in Parkinson's disease have
increased the scope of biological knowledge about the disease over the past decade. We …

[HTML][HTML] A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

D Chang, MA Nalls, IB Hallgrímsdóttir, J Hunkapiller… - Nature …, 2017 - nature.com
Common variant genome-wide association studies (GWASs) have, to date, identified> 24
risk loci for Parkinson's disease (PD). To discover additional loci, we carried out a GWAS …

Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease

L Pihlstrøm, G Axelsson, KA Bjørnarå, N Dizdar… - Neurobiology of …, 2013 - Elsevier
Genome-wide association studies have identified a number of susceptibility loci in sporadic
Parkinson's disease (PD). Recent larger studies and meta-analyses have greatly expanded …

Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk

MA Nalls, C Blauwendraat, CL Vallerga, K Heilbron… - BioRxiv, 2019 - biorxiv.org
We performed the largest genome-wide association study of PD to date, involving the
analysis of 7.8 M SNPs in 37.7 K cases, 18.6 K UK Biobank proxy-cases, and 1.4 M controls …

[HTML][HTML] Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

MA Nalls, N Pankratz, CM Lill, CB Do, DG Hernandez… - Nature …, 2014 - nature.com
We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty …

[HTML][HTML] Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

International Parkinson Disease Genomics Consortium - The Lancet, 2011 - Elsevier
BACKGROUND: Genome-wide association studies (GWAS) for Parkinson's disease have
linked two loci (MAPT and SNCA) to risk of Parkinson's disease. We aimed to identify novel …

Multi-ancestry genome-wide association meta-analysis of Parkinson's disease

JJ Kim, D Vitale, DV Otani, MM Lian, K Heilbron… - Nature …, 2024 - nature.com
Although over 90 independent risk variants have been identified for Parkinson's disease
using genome-wide association studies, most studies have been performed in just one …

Identification of candidate Parkinson disease genes by integrating genome-wide association study, expression, and epigenetic data sets

DA Kia, D Zhang, S Guelfi, C Manzoni… - JAMA …, 2021 - jamanetwork.com
Importance Substantial genome-wide association study (GWAS) work in Parkinson disease
(PD) has led to the discovery of an increasing number of loci shown reliably to be associated …

Identification of risk loci for Parkinson disease in Asians and comparison of risk between Asians and Europeans: a genome-wide association study

JN Foo, EGY Chew, SJ Chung, R Peng… - JAMA …, 2020 - jamanetwork.com
Importance Large-scale genome-wide association studies in the European population have
identified 90 risk variants associated with Parkinson disease (PD); however, there are …

Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study

A Elbaz, LM Nelson, H Payami, JPA Ioannidis… - The Lancet …, 2006 - thelancet.com
Background A genome-wide association study identified 13 single-nucleotide
polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale …