Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
MA Nalls, C Blauwendraat, CL Vallerga… - The Lancet …, 2019 - thelancet.com
Background Genome-wide association studies (GWAS) in Parkinson's disease have
increased the scope of biological knowledge about the disease over the past decade. We …
increased the scope of biological knowledge about the disease over the past decade. We …
[HTML][HTML] A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
D Chang, MA Nalls, IB Hallgrímsdóttir, J Hunkapiller… - Nature …, 2017 - nature.com
Common variant genome-wide association studies (GWASs) have, to date, identified> 24
risk loci for Parkinson's disease (PD). To discover additional loci, we carried out a GWAS …
risk loci for Parkinson's disease (PD). To discover additional loci, we carried out a GWAS …
Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease
L Pihlstrøm, G Axelsson, KA Bjørnarå, N Dizdar… - Neurobiology of …, 2013 - Elsevier
Genome-wide association studies have identified a number of susceptibility loci in sporadic
Parkinson's disease (PD). Recent larger studies and meta-analyses have greatly expanded …
Parkinson's disease (PD). Recent larger studies and meta-analyses have greatly expanded …
Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk
MA Nalls, C Blauwendraat, CL Vallerga, K Heilbron… - BioRxiv, 2019 - biorxiv.org
We performed the largest genome-wide association study of PD to date, involving the
analysis of 7.8 M SNPs in 37.7 K cases, 18.6 K UK Biobank proxy-cases, and 1.4 M controls …
analysis of 7.8 M SNPs in 37.7 K cases, 18.6 K UK Biobank proxy-cases, and 1.4 M controls …
[HTML][HTML] Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty …
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty …
[HTML][HTML] Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies
International Parkinson Disease Genomics Consortium - The Lancet, 2011 - Elsevier
BACKGROUND: Genome-wide association studies (GWAS) for Parkinson's disease have
linked two loci (MAPT and SNCA) to risk of Parkinson's disease. We aimed to identify novel …
linked two loci (MAPT and SNCA) to risk of Parkinson's disease. We aimed to identify novel …
Multi-ancestry genome-wide association meta-analysis of Parkinson's disease
Although over 90 independent risk variants have been identified for Parkinson's disease
using genome-wide association studies, most studies have been performed in just one …
using genome-wide association studies, most studies have been performed in just one …
Identification of candidate Parkinson disease genes by integrating genome-wide association study, expression, and epigenetic data sets
Importance Substantial genome-wide association study (GWAS) work in Parkinson disease
(PD) has led to the discovery of an increasing number of loci shown reliably to be associated …
(PD) has led to the discovery of an increasing number of loci shown reliably to be associated …
Identification of risk loci for Parkinson disease in Asians and comparison of risk between Asians and Europeans: a genome-wide association study
JN Foo, EGY Chew, SJ Chung, R Peng… - JAMA …, 2020 - jamanetwork.com
Importance Large-scale genome-wide association studies in the European population have
identified 90 risk variants associated with Parkinson disease (PD); however, there are …
identified 90 risk variants associated with Parkinson disease (PD); however, there are …
Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study
Background A genome-wide association study identified 13 single-nucleotide
polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale …
polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale …
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