The key link between renin–angiotensin system (RAS) and COVID-19 is ACE2 (angiotensin-
converting enzyme 2), which acts as a double-edged sword, because ACE2 increases the …

Abstract Angiotensin-converting enzyme 2 (ACE2) has been recognized as a potential entry
receptor for SARS-CoV-2 infection. Binding of SARS-CoV-2 to ACE2 allows engagement …

ABSTRACT COVID-19, caused by infection with SARS-CoV-2, is a disease characterised by
cough, fever and fatigue, which progresses to life-threatening lung injury in approximately …

Since the beginning of the twenty-first century, epidemic outbreaks of deadly pneumonia
have been caused by three coronaviruses: severe acute respiratory syndrome (SARS) …

During the spread of the severe acute respiratory syndrome coronavirus-2, some reports of
data still emerging and in need of full analysis indicate that certain groups of patients are at …

Blockers of the renin-angiotensin system (RAS) have been reported to increase the
angiotensin converting enzyme (ACE) 2, the cellular receptor of SARS-CoV-2, and thus the …

There is current debate concerning the use of angiotensin-converting enzyme (ACE)
inhibitors or angiotensin II type 1 receptor blockers (ARBs), for hypertension management …

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the pathogen of
coronavirus disease 2019 (COVID‐19), caused the outbreak escalated to pandemic …

Highlights•The angiotensin-converting enzyme 2 (ACE-2) facilitates access of SARS-CoV-2
in cells.•Therapeutic modulation of ACE-2 could be of clinical benefit.•Drugs acting on RAS …

This article reviews the correlation between angiotensin‐converting enzyme 2 (ACE2) and
severe risk factors for coronavirus disease 2019 (COVID‐19) and the possible mechanisms …