Musculoskeletal pain is a condition that characterises several diseases and represents a
constantly growing issue with enormous socio-economic burdens, highlighting the …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Acutely, pain serves to protect us from potentially harmful stimuli, however damage to the
somatosensory system can cause maladaptive changes in neurons leading to chronic pain …

Chronic pain is a major socioeconomic burden globally. The most frequent origin of chronic
pain is musculoskeletal. In inflammatory musculoskeletal diseases such as rheumatoid …

Musculoskeletal pain is an extensive societal challenge, due to the large population
affected, an increased expected life span, and the lack of efficient prevention and treatment …

Objectives Osteoarthritis (OA) is the leading cause of musculoskeletal pain and functional
disability worldwide, affecting a growing number of individuals in the western society …

Pain is the defining symptom of osteoarthritis (OA), yet available treatment options, of which
NSAIDs are the most common, provide inadequate pain relief and are associated with …

Until recently, most clinicians considered chronic pain to be typically due to ongoing
peripheral nociceptive input (ie, damage or inflammation) in the region of the body where …

Musculoskeletal pain (excluding bone cancer pain) affects more than 30% of the global
population and imposes an enormous burden on patients, families, and caregivers related to …

The aim of this Review is to give a short presentation of the manifestations, assessment
methods, and mechanisms underlying localized and widespread musculoskeletal pain …