Nucleic acid detection by isothermal amplification and the collateral cleavage of reporter
molecules by CRISPR-associated enzymes is a promising alternative to quantitative PCR …

CRISPR-based assays for the detection of nucleic acids are highly specific, yet they are not
fast, sensitive or easy to use. Here we report a one-step fluorescence assay for the detection …

The December 2019 outbreak of a novel respiratory virus, SARS-CoV-2, has become an
ongoing global pandemic due in part to the challenge of identifying symptomatic …

Extensive testing is essential to break the transmission of SARS-CoV-2, which causes the
ongoing COVID-19 pandemic. Here, we present a CRISPR-based diagnostic assay that is …

The existing CRISPR-mediated diagnostic tests require a two-step procedure (DNA or RNA
amplification followed by CRISPR-mediated sequence-specific detection) for nucleic acid …

An outbreak of betacoronavirus severe acute respiratory syndrome (SARS)-CoV-2 began in
Wuhan, China in December 2019. COVID-19, the disease associated with SARS-CoV-2 …

Rapid, point-of-care (POC) diagnostics are essential to mitigate the impacts of current (and
future) epidemics; however, current methods for detecting severe acute respiratory …

The recent outbreak of betacoronavirus Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2), which is responsible for the Coronavirus Disease 2019 (COVID-19) global …

Type VI CRISPR-Cas systems have been repurposed for various applications such as gene
knockdown, viral interference, and diagnostics. However, the identification and …

Recent research suggests that SARS-CoV-2-infected individuals can be highly infectious
while asymptomatic or pre-symptomatic, and that an infected person may infect 5.6 other …