Despite representing a very important class of virulence proteins, the role of lipoproteins in
the pathogenesis of Mycobacterium tuberculosis remains elusive. In this study, we …

The success of Mycobacterium tuberculosis as a pathogen relies on its ability to regulate the
host immune response. M. tuberculosis can manipulate adaptive T cell responses indirectly …

Reductive evolution has endowed Mycobacterium tuberculosis (M. tb) with moonlighting in
protein functions. We demonstrate that RipA (Rv1477), a peptidoglycan hydrolase, activates …

Tuberculosis is a severe infectious disease caused by Mycobacterium tuberculosis (Mtb).
LpqT is a lipoprotein of Mtb identified as a candidate virulence factor by a high-throughput …

TLR2 recognizes components of Mycobacterium tuberculosis (Mtb) and initiates responses
by APCs that influence both innate and adaptive immunity. Mtb lipoproteins are an important …

The success of Mycobacterium tuberculosis depends on its ability to survive within host
macrophages. Here, M. tuberculosis avoids the acidic, hydrolytically competent environment …

TLR2-dependent cellular signaling in Mycobacterium tuberculosis-infected macrophages
causes apoptosis and inhibits class II major histocompatibility complex (MHC-II) molecules …

Mycobacterium tuberculosis (Mtb) virulence is decreased by genetic deletion of the
lipoprotein LprG, but the function of LprG remains unclear. We report that LprG expressed in …

RP105, phylogenetically related to Toll-like receptor (TLR)-4, is reported to facilitate B cell
activation by the TLR4-agonist lipopolysaccharide (LPS)—but to limit LPS-induced cytokine …

Autophagy is an ubiquitous homeostatic pathway in mammalian cells and plays a significant
role in host immunity. Substantial evidence indicates that the ability of Mycobacterium …