The proper distribution of proteins between the cytosol and various membrane-bound
compartments is crucial for the functionality of eukaryotic cells. This requires the cooperation …

The peroxisomal protein import machinery differs fundamentally from known translocons
(endoplasmic reticulum, mitochondria, chloroplasts, bacteria) as it allows membrane …

Peroxisomes constitute a dynamic compartment in all nucleated cells. They fulfill diverse
metabolic tasks in response to environmental changes and cellular demands. This …

Blobel and coworkers discovered in 1978 that peroxisomal proteins are synthesized on free
ribosomes in the cytosol and thus provided the grounds for the conception of peroxisomes …

The peroxisomal proteins (peroxins) that mediate the import of peroxisomal matrix proteins
have been identified. Recently, the purification of a functional peroxisomal translocon has …

Based on earlier suggestions that peroxisomes may have arisen from endosymbionts that
later lost their DNA, it was expected that protein transport into this organelle would have …

Peroxisomes import folded, even oligomeric, proteins, which distinguishes the peroxisomal
translocation machinery from the well-characterized translocons of other organelles. How …

The import of proteins into peroxisomes possesses many unusual features such as the
ability to import folded proteins, and a surprising diversity of targeting signals with differing …

Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and transported by the
shuttling receptor PEX5 to the peroxisomal membrane docking/translocation machinery …

Peroxisomes constitute a dynamic compartment of almost all eukaryotic cells. Depending on
environmental changes and cellular demands peroxisomes can acquire diverse metabolic …