Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes
SP Rendic, FP Guengerich - Archives of Toxicology, 2024 - Springer
Data are presented on the formation of potentially toxic metabolites of drugs that are
substrates of human drug metabolizing enzymes. The tabular data lists the formation of …
substrates of human drug metabolizing enzymes. The tabular data lists the formation of …
Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update
SP Rendic, FP Guengerich - Archives of toxicology, 2021 - Springer
This is an overview of the metabolic activation of drugs, natural products, physiological
compounds, and general chemicals by the catalytic activity of cytochrome P450 enzymes …
compounds, and general chemicals by the catalytic activity of cytochrome P450 enzymes …
Induction of drug-metabolizing enzymes: a path to the discovery of multiple cytochromes P450
AH Conney - Annual review of pharmacology and toxicology, 2003 - annualreviews.org
This article provides a personal account of the discovery of the induced synthesis of drug-
metabolizing enzymes and of subsequent research that led to the discovery of multiple …
metabolizing enzymes and of subsequent research that led to the discovery of multiple …
[引用][C] Toxicological implications of drug metabolism.
RM Welch - Pharmacological Reviews, 1978 - ASPET
Normally the duration and intensity of drug action are related to the rate at which the drug is
eliminated from the body. In most cases hepatic and renal clearances, as well as tissue …
eliminated from the body. In most cases hepatic and renal clearances, as well as tissue …
Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity
FP Guengerich - Toxicology letters, 1994 - Elsevier
About 30 different human cytochrome P450 (P450) enzymes have now been characterized
in considerable detail. It is possible to elucidate their catalytic specificities towards drugs …
in considerable detail. It is possible to elucidate their catalytic specificities towards drugs …
The importance of cytochrome P450 3A enzymes in drug metabolism
FP Guengerich, EMJ Gillam, MV Martin, T Baba… - Assessment of the use of …, 1994 - Springer
The biotransformation of drugs in the body has been appreciated for over a century (Keller
1842; Baumann and Preusse 1879; Jaffe 1879). Cytochrome P450 (P450) enzymes were …
1842; Baumann and Preusse 1879; Jaffe 1879). Cytochrome P450 (P450) enzymes were …
Survey of human oxidoreductases and cytochrome P450 enzymes involved in the metabolism of xenobiotic and natural chemicals
S Rendic, FP Guengerich - Chemical Research in Toxicology, 2015 - ACS Publications
Analyzing the literature resources used in our previous reports, we calculated the fractions of
the oxidoreductase enzymes FMO (microsomal flavin-containing monooxygenase), AKR …
the oxidoreductase enzymes FMO (microsomal flavin-containing monooxygenase), AKR …
A history of the roles of cytochrome P450 enzymes in the toxicity of drugs
FP Guengerich - Toxicological research, 2021 - Springer
The history of drug metabolism began in the 19th Century and developed slowly. In the mid-
20th Century the relationship between drug metabolism and toxicity became appreciated …
20th Century the relationship between drug metabolism and toxicity became appreciated …
Intersection of the roles of cytochrome P450 enzymes with xenobiotic and endogenous substrates: relevance to toxicity and drug interactions
FP Guengerich - Chemical research in toxicology, 2017 - ACS Publications
Today much is known about cytochrome P450 (P450) enzymes and their catalytic specificity,
but the range of reactions catalyzed by each still continues to surprise. Historically, P450s …
but the range of reactions catalyzed by each still continues to surprise. Historically, P450s …
Biotransformations leading to toxic metabolites: chemical aspect
AC Macherey, PM Dansette - The practice of medicinal chemistry, 2008 - Elsevier
Publisher Summary As drugs are usually foreign chemicals, history of concern for the
biotransformations of drugs leading to toxic metabolites formation is intrinsically linked to the …
biotransformations of drugs leading to toxic metabolites formation is intrinsically linked to the …