[HTML][HTML] Remodeling of retinal architecture in diabetic retinopathy: disruption of ocular physiology and visual functions by inflammatory gene products and pyroptosis

RP Homme, M Singh, A Majumder, AK George… - Frontiers in …, 2018 - frontiersin.org
Diabetic patients suffer from a host of physiological abnormalities beyond just those of
glucose metabolism. These abnormalities often lead to systemic inflammation via …

Pathological perturbations in diabetic retinopathy: hyperglycemia, AGEs, oxidative stress and inflammatory pathways

NS Sahajpal, RK Goel, A Chaubey… - Current Protein and …, 2019 - ingentaconnect.com
Diabetic retinopathy (DR) remains the leading cause of blindness in working-aged adults
around the world. The proliferative diabetic retinopathy (PDR) and diabetic macular edema …

[HTML][HTML] Cellular targets in diabetic retinopathy therapy

ML Rodríguez, I Millán, ÁL Ortega - World Journal of Diabetes, 2021 - ncbi.nlm.nih.gov
Despite the existence of treatment for diabetes, inadequate metabolic control triggers the
appearance of chronic complications such as diabetic retinopathy. Diabetic retinopathy is …

[HTML][HTML] Mechanistic insights into pathological changes in the diabetic retina: implications for targeting diabetic retinopathy

S Roy, TS Kern, B Song, C Stuebe - The American journal of pathology, 2017 - Elsevier
Increasing evidence points to inflammation as one of the key players in diabetes-mediating
adverse effects to the neuronal and vascular components of the retina. Sustained …

[HTML][HTML] Cross talks between oxidative stress, inflammation and epigenetics in diabetic retinopathy

RA Kowluru - Cells, 2023 - mdpi.com
Diabetic retinopathy, one of the most devastating complications of diabetes, is a
multifactorial progressing disease with a very complex etiology. Although many metabolic …

Perturbed biochemical pathways and associated oxidative stress lead to vascular dysfunctions in diabetic retinopathy

N Mahajan, P Arora, R Sandhir - Oxidative medicine and …, 2019 - Wiley Online Library
Diabetic retinopathy (DR) is a vascular insult that accompanies the hyperglycemic state.
Retinal vasculature holds a pivotal role in maintaining the integrity of the retina, and any …

Oxidative stress as the main target in diabetic retinopathy pathophysiology

C Olvera-Montano… - Journal of diabetes …, 2019 - search.proquest.com
Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus
(DM) causing vision impairment even at young ages. There are numerous mechanisms …

Oxidative stress as the main target in diabetic retinopathy pathophysiology

OM Cecilia, CG José Alberto, NP José… - Journal of diabetes …, 2019 - Wiley Online Library
Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus
(DM) causing vision impairment even at young ages. There are numerous mechanisms …

[HTML][HTML] Molecular mechanisms of diabetic retinopathy: potential therapeutic targets

M Coucha, SL Elshaer, WS Eldahshan… - Middle East African …, 2015 - journals.lww.com
Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults in United
States. Research indicates an association between oxidative stress and the development of …

The oxidative stress and mitochondrial dysfunction during the pathogenesis of diabetic retinopathy

MY Wu, GT Yiang, TT Lai, CJ Li - Oxidative medicine and …, 2018 - Wiley Online Library
Diabetic retinopathy is one of the most serious microvascular complications induced by
hyperglycemia via five major pathways, including polyol, hexosamine, protein kinase C, and …