Cyclooxygenase (COX; prostaglandin G/H synthase, EC 1.14. 99.1) catalyzes the first two
steps in the biosynthesis of prostaglandins (PGs). The two COX isoforms COX-1 and COX-2 …

▪ Abstract Cyclooxygenases-1 and-2 (COX-1 and COX-2, also known as prostaglandin H2
synthases-1 and-2) catalyze the committed step in prostaglandin synthesis. COX-1 and-2 …

Nonsteroidal anti-inflammatory drugs (NSAIDs) represent one of the most highly utilized
classes of pharmaceutical agents in medicine. All NSAIDs act through inhibiting …

Cyclooxygenase (COX) exists in two isoforms, COX-1 and COX-2. COX-1 is present and is
constitutively expressed in most cells and tissues, whereas COX-2 is felt to principally …

Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to
prostaglandins was first identified over 20 years ago. Drugs, like aspirin, that inhibit …

The cyclooxygenase isoenzymes (COX-1 and-2) catalyze the rate-limiting steps in
prostanoid biosynthesis. COX-1 and-2 genes encode two isoenzymes with overlapping yet …

▪ Abstract The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also
cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin …

Numerous studies implicate the cyclooxygenase 2 (COX2) enzyme and COX2-derived
prostanoids in various human diseases, and thus, much effort has been made to uncover the …

Despite the marked differences in their physiological roles, the structures and catalytic
functions of the cyclooxygenase isozymes COX-1 and-2 are virtually identical. Nevertheless …

▪ Abstract Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is
the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX …