[HTML][HTML] The PFC-LH-VTA pathway contributes to social deficits in IRSp53-mutant mice
Dopamine (DA) neurons in the ventral tegmental area (VTA) promote social brain functions
by releasing DA onto nucleus accumbens neurons, but it remains unclear how VTA neurons …
by releasing DA onto nucleus accumbens neurons, but it remains unclear how VTA neurons …
Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice
Social deficit is a major feature of neuropsychiatric disorders, including autism spectrum
disorders, schizophrenia, and attention-deficit/hyperactivity disorder, but its neural …
disorders, schizophrenia, and attention-deficit/hyperactivity disorder, but its neural …
Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior
Functional imaging and gene expression studies both implicate the medial prefrontal cortex
(mPFC), particularly deep-layer projection neurons, as a potential locus for autism …
(mPFC), particularly deep-layer projection neurons, as a potential locus for autism …
Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression
Social deficits are observed in diverse psychiatric disorders, including autism spectrum
disorders and schizophrenia. We found that mice lacking the excitatory synaptic signaling …
disorders and schizophrenia. We found that mice lacking the excitatory synaptic signaling …
[HTML][HTML] IRSp53 deletion in glutamatergic and GABAergic neurons and in male and female mice leads to distinct electrophysiological and behavioral phenotypes
IRSp53 (also known as BAIAP2) is an abundant excitatory postsynaptic scaffolding protein
implicated in autism spectrum disorders (ASD), schizophrenia, and attention …
implicated in autism spectrum disorders (ASD), schizophrenia, and attention …
[HTML][HTML] Balance between projecting neuronal populations of the nucleus accumbens controls social behavior in mice
J Le Merrer, B Detraux, J Gandía, A De Groote… - Biological …, 2024 - Elsevier
Background Deficient social interactions are a hallmark of major neuropsychiatric disorders,
and accumulating evidence points to altered social reward and motivation as key underlying …
and accumulating evidence points to altered social reward and motivation as key underlying …
[HTML][HTML] Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal …
C Numa, H Nagai, M Taniguchi, M Nagai… - Scientific reports, 2019 - nature.com
We recently reported that dopamine D1 receptor in the medial prefrontal cortex (mPFC) is
activated by subthreshold social defeat stress and suppresses the induction of depressive …
activated by subthreshold social defeat stress and suppresses the induction of depressive …
[HTML][HTML] Ventral hippocampal projections to the medial prefrontal cortex regulate social memory
Inputs from the ventral hippocampus (vHIP) to the medial prefrontal cortex (mPFC) are
implicated in several neuropsychiatric disorders. Here, we show that the vHIP-mPFC …
implicated in several neuropsychiatric disorders. Here, we show that the vHIP-mPFC …
The infralimbic cortex bidirectionally modulates mesolimbic dopamine neuron activity via distinct neural pathways
The ventral tegmental area (VTA) has been implicated in a number of psychiatric disorders,
including schizophrenia, depression, and bipolar disorder. One major regulator of the …
including schizophrenia, depression, and bipolar disorder. One major regulator of the …
[HTML][HTML] NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model
Emotional stress is considered a severe pathogenetic factor of psychiatric disorders.
However, the circuit mechanisms remain largely unclear. Using a three-chamber vicarious …
However, the circuit mechanisms remain largely unclear. Using a three-chamber vicarious …