Adrenal masses are a common problem affecting 3− 7% of the population. The majority turn
out to be benign adrenocortical adenomas, which may be functional or non‐functional. Much …

Adrenocortical neoplasms are the most frequent abnormality of the adrenal cortex. Most of
these lesions are clinically silent and are detected incidentally by ultrasound or computed …

The mechanisms of adrenocortical tumorigenesis are still not fully understood. Data from
clonal analysis, comparative genomic hybridization, and allelotyping suggest that it involves …

Modern imaging modalities lead to frequent detection of adrenal masses, most of them
incidental findings. Although the majority of adrenocortical and adrenomedullary tumors are …

Primary or adrenocorticotropin-independent adrenocortical tumors and hyperplasias
represent a heterogeneous group of adrenocortical neoplasms that arise from various …

Genetic tools for the analysis of human tumors have developed rapidly over the past 20
years. Adrenocortical neoplasms have been subject to multiple analyses using these new …

Whereas benign adrenocortical tumors are frequent in the population, adrenocortical
carcinoma (ACC) is a rare cancer. Significant advances in the understanding of the …

Objective: To review the existing literature for evidence that adrenocortical and
adrenomedullary tumours develop through a multistep process of carcinogenesis. Results …

Tumors of the adrenal cortex can be diagnosed by the investigation of clinical signs of
steroid excess or incidentally on medical imaging. Most tumors are unilateral and can be …

The genetic and histopathological backgrounds of adrenocortical tumorigenesis remain
poorly characterized. In other tissues, there is conclusive evidence that hyperplasia and …