Challenges in clinical development of mesenchymal stromal/stem cells: concise review

I Mastrolia, EM Foppiani, A Murgia… - Stem cells …, 2019 - academic.oup.com
Identified 50 years ago, mesenchymal stromal/stem cells (MSCs) immediately generated a
substantial interest among the scientific community because of their differentiation plasticity …

Mesenchymal stromal cells anno 2019: dawn of the therapeutic era? Concise review

MJ Hoogduijn, E Lombardo - Stem cells translational medicine, 2019 - academic.oup.com
Summary 2018 was the year of the first marketing authorization of an allogeneic stem cell
therapy by the European Medicines Agency. The authorization concerns the use of …

[HTML][HTML] Mesenchymal stromal cells: new directions

A Keating - Cell stem cell, 2012 - cell.com
Research into mesenchymal stromal/stem cells (MSCs) has been particularly exciting in the
past five years. Our understanding of mechanisms of MSC-mediated tissue regeneration has …

Mesenchymal stromal cells; a new horizon in regenerative medicine

S Tavakoli, HR Ghaderi Jafarbeigloo… - Journal of cellular …, 2020 - Wiley Online Library
In recent decades, mesenchymal stromal cells (MSCs) biomedical utilizing has attracted
worldwide growing attention. After the first report of the human MSCs obtaining from the …

Mesenchymal stromal/stem cells in regenerative medicine and tissue engineering

REB Fitzsimmons, MS Mazurek, A Soos… - Stem cells …, 2018 - Wiley Online Library
As a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs)
have emerged as a versatile and frequently utilized cell source in the fields of regenerative …

Q&A: mesenchymal stem cells—where do they come from and is it important?

IR Murray, B Péault - BMC biology, 2015 - Springer
Mesenchymal stem—or stromal—cells (MSCs) have been administered in hundreds of
clinical trials for multiple indications, making them some of the most commonly used …

Mesenchymal stromal cells: clinical challenges and therapeutic opportunities

J Galipeau, L Sensébé - Cell stem cell, 2018 - cell.com
Mesenchymal stromal cells (MSCs) have been the subject of clinical trials for more than a
generation, and the outcomes of advanced clinical trials have fallen short of expectations …

Therapeutic use of mesenchymal stromal cells: the need for inclusive characterization guidelines to accommodate all tissue sources and species

A Wright, ML Arthaud-Day, ML Weiss - Frontiers in cell and …, 2021 - frontiersin.org
Following their discovery over 50 years ago, mesenchymal stromal cells (MSCs) have
become one of the most studied cellular therapeutic products by both academia and industry …

The therapeutic potential of mesenchymal stromal cells for regenerative medicine: current knowledge and future understandings

M Merimi, R El-Majzoub, L Lagneaux… - Frontiers in Cell and …, 2021 - frontiersin.org
In recent decades, research on the therapeutic potential of progenitor cells has advanced
considerably. Among progenitor cells, mesenchymal stromal cells (MSCs) have attracted …

Concise review: mesenchymal stem cells: from roots to boost

A Andrzejewska, B Lukomska, M Janowski - Stem cells, 2019 - academic.oup.com
It was shown as long as half a century ago that bone marrow is a source of not only
hematopoietic stem cells, but also stem cells of mesenchymal tissues. Then the term …