Bone marrow transplantation therapy relies on the life-long regenerative capacity of
haematopoietic stem cells (HSCs),. HSCs present a complex variety of regenerative …

Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells
(HSCs), leading to clonal haematopoiesis. These lesions are precursors for blood cancers …

The human blood system is maintained through the differentiation and massive amplification
of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this …

Haematopoietic stem cells (HSCs) are derived early from embryonic precursors, such as
haemogenic endothelial cells and pre-haematopoietic stem cells (pre-HSCs), the molecular …

Limited knowledge of the mechanisms that govern the self-renewal of human
haematopoietic stem cells (HSCs), and why this fails in culture, have impeded the expansion …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown. The age-related acquisition of …

Fetal hematopoietic stem cells (HSCs) undergo a developmental switch to become adult
HSCs with distinct functional properties. To better understand the molecular mechanisms …

Haematopoietic stem cells (HSCs) arise in the developing aorta during embryogenesis. The
number of HSC clones born has been estimated through transplantation, but experimental …

The formation of red blood cells begins with the differentiation of multipotent haematopoietic
progenitors. Reconstructing the steps of this differentiation represents a general challenge in …

Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of
haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly …