Background—The ubiquitin proteasome system maintains a dynamic equilibrium of proteins
and prevents accumulation of damaged and misfolded proteins, yet its role in human cardiac …

The ubiquitin–proteasome system (UPS) plays a critical role in removing unwanted
intracellular proteins and is involved in protein quality control, signalling and cell death …

Adequate protein turnover is essential for cardiac homeostasis. Different protein quality
controls are involved in the maintenance of protein homeostasis, including molecular …

Protein degradation by the ubiquitin‐proteasome pathway plays an important role in a
variety of fundamental cellular processes, including cell cycle regulation, transcription …

The ubiquitin-proteasome system (UPS) is the major nonlysosomal pathway for intracellular
protein degradation, generally requiring a covalent linkage of one or more chains of …

Maintenance of protein quality control is a critical function of the ubiquitin proteasome
system (UPS). Evidence is rapidly mounting to link proteasome dysfunction with a multitude …

The ubiquitin-proteasome system (UPS) is responsible for turnover of most cellular proteins
in eukaryotes. Protein degradation by the UPS serves quality control and regulatory …

Proteasomes are the main non-lysosomal multicatalytic protease complexes that are
involved in the degradation of most intracellular proteins. The substrate proteins are marked …

Intensive investigations into the pathophysiological significance of the proteasome in the
heart did not start until the beginning of the past decade but exciting progress has been …

The ubiquitin-proteasome system (UPS) is responsible for the degradation of most cellular
proteins. Alterations in cardiac UPS, including changes in the degradation of regulatory …