Background and Objectives The Spectra Optia® continuous mononuclear cell (CMNC
apheresis) system has emerged as the preferred device in peripheral blood stem cell …

Terumo BCT recently introduced a new system for mononuclear cell (MNC) collection that
uses a Spectra Optia apheresis machine equipped with a redesigned disposable kit and …

The Spectra Optia apheresis system is a newer centrifugation‐based device that in
comparison with the COBE Spectra includes features that enhance procedure automation …

Purpose We evaluated the Optia® continuous mononuclear collection (CMNC) system for
hematopoietic progenitor cell‐apheresis (HPC‐A) collection (Terumo BCT, Lakewood, CO) …

Background An increasing demand for human lymphocytes require an efficient, reliable and
reproducible lymphocyte process. Here, we compare the Spectra Optia® CMNC protocol …

Background and Objectives Leukapheresis is an important source for mononuclear cells
(MNC s) used in adoptive immunotherapies. Differences in the apheresis technology …

Background Peripheral hematopoietic stem cell (HSC) collections are needed for
autologous hematopoietic stem cell transplantation (HSCT). Since 2015, our institution has …

Background Unstimulated mononuclear cell (MNC) apheresis plays a role in the generation
of donor lymphocytes (DLIs; healthy donors) and in extracorporeal photopheresis (ECP; …

Background Recently, novel protocol utilizing Continuous Mononuclear Cell Collection
(cMNC) have been introduced for leukapheresis. We compared the efficacy of cMNC with an …

BACKGROUND The manufacturing of cellular products for immunotherapy, such as chimeric
antigen receptor T cells, requires successful collection of mononuclear cells. Collections …