Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by clonal
proliferation of plasma cells and a heterogenous genomic landscape. Copy number and …

Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …

Genomic instability is an essential feature of cancer cells. The somatic mutation theory
suggests that along with inherited ones, the changes in DNA caused by environmental …

Human multiple myeloma tumor cell lines (HMCLs) have been a cornerstone of research in
multiple myeloma (MM) and have helped to shape our understanding of molecular …

Multiple myeloma (MM) and its precursor condition MGUS are characterized by
chromosomal aberrations. Here, we comprehensively characterize the order of occurrence …

Multiple myeloma (MM) is a genetically complex disease that evolves from pre-malignant
stages, such as monoclonal gammaopathy of undetermined significance and smouldering …

To obtain a comprehensive genomic profile of presenting multiple myeloma cases we
performed high-resolution single nucleotide polymorphism mapping array analysis in 114 …

Background Multiple myeloma (MM) is a heterogeneous disease with different patterns of
clonal evolution and a complex tumor microenvironment, representing a challenge for …

Multiple myeloma (MM) is a plasma cell malignancy preceded by a premalignant stage,
named monoclonal gammopathy of undetermined significance (MGUS), and often a …

To elucidate the mechanisms underlying relapse from chemotherapy in multiple myeloma,
we performed a longitudinal study of 33 patients entered into Total Therapy protocols …