Vesicular trafficking and selective autophagy have emerged as central processes in cellular
remodeling. In reticulocytes, this includes enucleation and the elimination of all membrane …

The maturation of reticulocytes into functional erythrocytes is a complex process requiring
extensive cytoplasmic and plasma membrane remodeling, cytoskeletal rearrangements and …

During reticulocyte maturation, hematopoietic progenitors undergo numerous changes to
reach the final functional stage which concludes with the release of reticulocytes and …

Secretion of exosomes during reticulocyte maturation is an integral part of the red cell
differentiation program and illustrates specific mechanisms in terms of biogenesis, protein …

During the differentiation of erythroid cells, a vast program of maturation takes place, leading
to decay or elimination of organelles, including the nucleus, mitochondria, ribosomes …

Erythrocytes are anucleated cells devoid of organelles. Expulsion of the nucleus from
erythroblasts leads to the formation of reticulocytes, which still contain organelles. The …

Mitochondrial clearance is a well recognized but poorly understood biologic process, and
reticulocytes, which undergo programmed mitochondrial clearance, provide a useful model …

Erythropoiesis occurs mostly in bone marrow and ends in blood stream. Mature red blood
cells are generated from multipotent hematopoietic stem cells, through a complex maturation …

Reticulocyte maturation into erythrocytes is the final step of erythropoiesis that occurs in the
blood circulation. This terminal differentiation period corresponds to a cellular remodeling …

Changes to the membrane proteins and rearrangement of the cytoskeleton must occur for a
reticulocyte to mature into a red blood cell (RBC). Different mechanisms of reticulocyte …