Curcumin and LOXblock-1 ameliorate ischemia-reperfusion induced inflammation and acute kidney injury by suppressing the semaphorin-plexin pathway.

F Kar, C Hacioglu, H Senturk, DB Donmez, G Kanbak… - Life Sciences, 2020 - Elsevier
Abstract Aims Ischemia/reperfusion (I/R) is one of the most important causes of acute kidney
injury (AKI), a clinical syndrome with kidney dysfunction and high mortality rates. New …

Inhibition of semaphorin-3a suppresses lipopolysaccharide-induced acute kidney injury

X Tian, H Gan, Y Zeng, H Zhao, R Tang… - Journal of Molecular …, 2018 - Springer
Abstract Semaphorin-3a (Sema3A), a soluble axon guidance cue, appears to play an
important role in the development of acute kidney injury (AKI) and has been regarded as an …

Protective role of curcumin on renal ischemia reperfusion injury via attenuating the inflammatory mediators and Caspase-3

FH Liu, WJ Ni, GK Wang, JJ Zhang - Cellular and Molecular Biology, 2016 - cellmolbiol.org
Renal ischemia/reperfusion (I/R) damage may arise due to nephron sparing surgery in
patient with a solitary kidney of restricted renal parenchymas. Apoptosis, inflammation and …

[HTML][HTML] Molecular mechanisms of curcumin renoprotection in experimental acute renal injury

Y Fan, H Chen, H Peng, F Huang, J Zhong… - Frontiers in …, 2017 - frontiersin.org
As a highly perfused organ, the kidney is especially sensitive to ischemia and reperfusion.
Ischemia-reperfusion (IR)-induced acute kidney injury (AKI) has a high incidence during the …

Semaphorin 3A inactivation suppresses ischemia-reperfusion-induced inflammation and acute kidney injury

P Ranganathan, C Jayakumar… - American Journal …, 2014 - journals.physiology.org
Recent studies show that guidance molecules that are known to regulate cell migration
during development may also play an important role in adult pathophysiologic states. One …

The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats

J Zhang, L Tang, GS Li, J Wang - Renal Failure, 2018 - Taylor & Francis
The present study aimed to explore the protective mechanism of curcumin-precondition in
renal ischemia-reperfusion (I/R) injury. Thirty male SD rats were randomly equally divided …

[HTML][HTML] Eriocitrin attenuates ischemia reperfusion-induced oxidative stress and inflammation in rats with acute kidney injury by regulating the dual-specificity …

J Xu, L Ma, P Fu - Annals of Translational Medicine, 2021 - ncbi.nlm.nih.gov
Background Ischemia reperfusion (IR)-induced acute kidney injury (AKI) is accompanied by
increased inflammatory response and oxidative stress. Eriocitrin is a flavonoid that is mainly …

Curcumin protects against renal ischemia/reperfusion injury by regulating oxidative stress and inflammatory response

X Cui, L Lin, X Sun, L Wang… - … and Alternative Medicine, 2021 - Wiley Online Library
Objective. The aim of this study was to explore the pharmacological effects of curcumin on
oxidative stress and inflammatory response of renal dysfunction induced by renal …

LoxBlock-1 or Curcumin attenuates liver, pancreas and cardiac ferroptosis, oxidative stress and injury in Ischemia/reperfusion-damaged rats by facilitating ACSL/GPx4 …

F Kar, F Yıldız, C Hacioglu, E Kar, DB Donmez… - Tissue and Cell, 2023 - Elsevier
In this study, the effects of the pretreatment of Curcumin and LoxBlock-1 on liver, pancreas,
and cardiac dysfunction following Ischemia-Reperfusion-induced (IR) Acute Kidney Injury …

[HTML][HTML] Administration of curcumin protects kidney tubules against renal ischemia-reperfusion injury (RIRI) by modulating nitric oxide (NO) signaling pathway

F Liu, W Ni, J Zhang, G Wang, F Li… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: To explore the protective effect of curcumin on renal ischemia-reperfusion
injury (RIRI) in rats, and its influence on nephridial tissue's NO and cGMP levels as well as …