Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease
AF Schmidt, NB Hunt, M Gordillo-Marañón… - Nature …, 2021 - nature.com
Abstract Development of cholesteryl ester transfer protein (CETP) inhibitors for coronary
heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from …
heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from …
Cholesteryl Ester Transfer Protein Inhibition for Preventing Cardiovascular Events: JACC Review Topic of the Week
Cholesteryl ester transfer protein (CETP) facilitates exchange of triglycerides and cholesteryl
ester between high-density lipoprotein (HDL) and apolipoprotein B100–containing …
ester between high-density lipoprotein (HDL) and apolipoprotein B100–containing …
Joint genetic inhibition of PCSK9 and CETP and the association with coronary artery disease: a factorial mendelian randomization study
Importance Cholesteryl ester transfer protein inhibition (CETP) has been shown to increase
levels of high-density lipoprotein cholesterol (HDL-C) and reduce levels of low-density …
levels of high-density lipoprotein cholesterol (HDL-C) and reduce levels of low-density …
Cholesteryl ester transfer protein inhibitors: from high-density lipoprotein cholesterol to low-density lipoprotein cholesterol lowering agents?
NS Nurmohamed, M Ditmarsch… - Cardiovascular …, 2022 - academic.oup.com
Cholesteryl ester transfer protein (CETP) is a liver-synthesized glycoprotein whose main
functions are facilitating transfer of both cholesteryl esters from high-density lipoprotein …
functions are facilitating transfer of both cholesteryl esters from high-density lipoprotein …
Cholesteryl ester transfer protein inhibitors and cardiovascular outcomes: a systematic review and meta-analysis of randomized controlled trials
H Taheri, KB Filion, SB Windle, P Reynier… - Cardiology, 2020 - karger.com
Background: Cholesteryl ester transfer protein (CETP) inhibitors increase serum high-
density lipoprotein cholesterol (HDL-c) concentration; however, their impact on …
density lipoprotein cholesterol (HDL-c) concentration; however, their impact on …
Obicetrapib: reversing the tide of CETP inhibitor disappointments
JJP Kastelein, A Hsieh, MR Dicklin… - Current Atherosclerosis …, 2024 - Springer
Abstract Purpose of Review To discuss the history of cardiovascular outcomes trials of
cholesteryl ester transfer protein (CETP) inhibitors and to describe obicetrapib, a next …
cholesteryl ester transfer protein (CETP) inhibitors and to describe obicetrapib, a next …
[HTML][HTML] Cholesteryl ester transfer protein (CETP) deficiency and CETP inhibitors
H Mabuchi, A Nohara, A Inazu - Molecules and cells, 2014 - Elsevier
Epidemiologic studies have shown that low-density lipoprotein cholesterol (LDL-C) is a
strong risk factor, whilst high-density lipoprotein cholesterol (HDL-C) reduces the risk of …
strong risk factor, whilst high-density lipoprotein cholesterol (HDL-C) reduces the risk of …
Targeting cholesteryl ester transfer protein for the prevention and management of cardiovascular disease
PJ Barter, JJP Kastelein - Journal of the American College of Cardiology, 2006 - jacc.org
Epidemiologic studies have shown that the concentration of high-density lipoprotein
cholesterol (HDL-C) is a strong, independent, inverse predictor of coronary heart disease …
cholesterol (HDL-C) is a strong, independent, inverse predictor of coronary heart disease …
Oral cholesteryl ester transfer protein (CETP) inhibitors: a potential new approach for treating coronary artery disease
JA Sikorski - Journal of medicinal chemistry, 2006 - ACS Publications
Cholesteryl ester transfer protein (CETP), a plasma glycoprotein, mediates the transfer of
neutral lipids in the blood among various lipoproteins. 1, 2 Because of their poor water …
neutral lipids in the blood among various lipoproteins. 1, 2 Because of their poor water …
Cholesteryl ester transfer protein inhibition as a strategy to reduce cardiovascular risk
Human and rabbit plasma contain a cholesteryl ester transfer protein (CETP) that promotes
net mass transfers of cholesteryl esters from high density lipoproteins (HDL) to other plasma …
net mass transfers of cholesteryl esters from high density lipoproteins (HDL) to other plasma …