While mechanical stimulation is known to regulate a wide range of biological processes at
the cellular and tissue levels, its medical use for tissue regeneration and rehabilitation has …

Nature has abundant examples of soft muscular systems; examples of these in the human
body are the stomach, tongue, diaphragm and heart. In fact, musculature has been deemed …

Cells feel the forces exerted on them by the surrounding extracellular matrix (ECM)
environment and respond to them. While many cell fate processes are dictated by these …

Severe skeletal muscle injuries are common and can lead to extensive fibrosis, scarring,
and loss of function. Clinically, no therapeutic intervention exists that allows for a full …

To successfully induce tissue repair or regeneration in vivo, bioengineered constructs must
possess both optimal bioactivity and mechanical strength. This is because cell interaction …

Biomaterials engineered with specific bioactive ligands, tunable mechanical properties and
complex architecture have emerged as powerful tools to probe cell sensing and response to …

Elastic protein-based machines (bioelastic materials) can be designed to perform diverse
biological energy conversions. Coupled with the remarkable energy-conversion capacity of …

Although skeletal muscle is highly regenerative following injury or disease, endogenous self‐
regeneration is severely impaired in conditions of volume traumatic muscle loss …

Scaffold-free systems have emerged as viable approaches for engineering load-bearing
tissues. However, the tensile properties of engineered tissues have remained far below the …

Active biomaterials offer novel approaches to study mechanotransduction in mammalian
cells. These material systems probe cellular responses by dynamically modulating their …