Endocrine, Metabolic, and Immune Pathogenesis of Postmenopausal Osteoporosis. Is there a Therapeutic Role in Natural Products?

G Lisco, D Triggiani, VA Giagulli… - … Metabolic & Immune …, 2023 - ingentaconnect.com
Background: Bone health relies on the equilibrium between resorption and new bone
generation. Postmenopausal osteoporosis depends on estrogen deficiency which favorite …

[HTML][HTML] The role of the immune system in the physiopathology of osteoporosis

V Cagnetta, V Patella - Clinical cases in mineral and bone …, 2012 - ncbi.nlm.nih.gov
The close anatomical relationship between the immune system, estrogen deficiency and
bone loss has been recognized for centuries but the existence of a functional relationship …

Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis

W Zhang, R Gao, X Rong, S Zhu, Y Cui… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis is a skeletal system disease characterized by low bone mass and altered bone
microarchitecture, with an increased risk of fractures. Classical theories hold that …

[HTML][HTML] Osteoporosis: Pathophysiology and therapeutic options

U Föger-Samwald, P Dovjak, U Azizi-Semrad… - EXCLI …, 2020 - ncbi.nlm.nih.gov
Osteoporosis is a metabolic bone disease that, on a cellular level, results from osteoclastic
bone resorption not compensated by osteoblastic bone formation. This causes bones to …

[PDF][PDF] Osteoporosis in the view of osteoimmunology: common feature underlined by different pathogenic mechanisms

D Flegar, A ŠUĆUR, A MARKOTIĆ, N KOVAČIĆ… - Periodicum …, 2015 - hrcak.srce.hr
Osteoporosis is a skeletal disorder characterized by low bone mineral density and
microarchitectural changes with increased susceptibility to fractures, resulting in significant …

Postmenopausal osteoporosis: the role of immune system cells

MF Faienza, A Ventura, F Marzano… - Journal of Immunology …, 2013 - Wiley Online Library
In the last years, new evidences of the relationship between immune system and bone have
been accumulated both in animal models and in humans affected by bone disease, such as …

[PDF][PDF] Pharmacological agents and natural compounds: available treatments for osteoporosis.

M Martiniakova, M Babikova, R Omelka - Journal of Physiology & …, 2020 - jpp.krakow.pl
Osteoporosis, a systemic skeletal disease characterized by a decrease in bone mass and
deterioration of bone structure leading to an increased risk of fragility fractures, represents …

Secondary osteoporosis and metabolic bone diseases

MM Sobh, M Abdalbary, S Elnagar, E Nagy… - Journal of Clinical …, 2022 - mdpi.com
Fragility fracture is a worldwide problem and a main cause of disability and impaired quality
of life. It is primarily caused by osteoporosis, characterized by impaired bone quantity and or …

Osteoimmunology and beyond

L Ginaldi, M De Martinis - Current medicinal chemistry, 2016 - ingentaconnect.com
Objective: Osteoimmunology investigates interactions between skeleton and immune
system. In the light of recent discoveries in this field, a new reading register of osteoporosis …

A mini review on osteoporosis: from biology to pharmacological management of bone loss

KY Chin, BN Ng, MKI Rostam… - Journal of Clinical …, 2022 - mdpi.com
Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass
and microarchitecture, which compromises bone strength. It is a complex multifactorial …