Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility
Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
Thirteen common susceptibility loci have been reproducibly associated with cutaneous
malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis …
malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis …
[HTML][HTML] Melanoma genetics: recent findings take us beyond well-traveled pathways
Genetic linkage and candidate gene studies have identified a number of genes involved in
melanoma susceptibility, such as MC1R and CDKN2A, via the endophenotypes of …
melanoma susceptibility, such as MC1R and CDKN2A, via the endophenotypes of …
Genome-wide association study identifies three loci associated with melanoma risk
We report a genome-wide association study of melanoma conducted by the GenoMEL
consortium based on 317K tagging SNPs for 1,650 selected cases and 4,336 controls, with …
consortium based on 317K tagging SNPs for 1,650 selected cases and 4,336 controls, with …
Comprehensive field synopsis and systematic meta-analyses of genetic association studies in cutaneous melanoma
F Chatzinasiou, CM Lill, K Kypreou… - Journal of the …, 2011 - academic.oup.com
Background Although genetic studies have reported a number of loci associated with
cutaneous melanoma (CM) risk, a comprehensive synopsis of genetic association studies …
cutaneous melanoma (CM) risk, a comprehensive synopsis of genetic association studies …
[HTML][HTML] Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma
Genome-wide association studies have identified 21 susceptibility loci associated with
melanoma. These loci implicate genes affecting pigmentation, nevus count, telomere …
melanoma. These loci implicate genes affecting pigmentation, nevus count, telomere …
Genome-wide association study identifies three new melanoma susceptibility loci
We report a genome-wide association study for melanoma that was conducted by the
GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and …
GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and …
The genetics of melanoma: recent advances
VK Hill, JJ Gartner, Y Samuels… - Annual review of …, 2013 - annualreviews.org
Cutaneous malignant melanoma results from the interplay of genetic, host, and
environmental factors. Genetic factors implicated in melanoma etiology include inherited …
environmental factors. Genetic factors implicated in melanoma etiology include inherited …
Massively parallel reporter assays and variant scoring identified functional variants and target genes for melanoma loci and highlighted cell-type specificity
E Long, J Yin, KM Funderburk, M Xu, J Feng… - The American Journal of …, 2022 - cell.com
The most recent genome-wide association study (GWAS) of cutaneous melanoma identified
54 risk-associated loci, but functional variants and their target genes for most have not been …
54 risk-associated loci, but functional variants and their target genes for most have not been …
Genome-wide association study identifies novel loci predisposing to cutaneous melanoma
We performed a multistage genome-wide association study of melanoma. In a discovery
cohort of 1804 melanoma cases and 1026 controls, we identified loci at chromosomes …
cohort of 1804 melanoma cases and 1026 controls, we identified loci at chromosomes …