Recent studies combining pharmacological, behavioral, electrophysiological and molecular
approaches indicate that depression results from maladaptive neuroplastic processes …

Major depressive disorder (MDD) is a mood disorder of multifactorial origin affecting millions
of people worldwide. The alarming estimated rates of prevalence and relapse make it a …

The neuroinflammatory basis of depression encompasses the detrimental role of otherwise
supportive non-neuronal cells and neuroinflammation in hampering neuronal function …

Since the 1960s, when the first tricyclic and monoamine oxidase inhibitor antidepressant
drugs were introduced, most of the ensuing agents were designed to target similar brain …

Depressive disorders are complex, multifactorial mental disorders with unknown
neurobiology. Numerous theories aim to explain the pathophysiology. According to the …

Major depressive disorder (MDD) is one of the most common neuropsychiatric disorders
affecting over one-fifth of the population worldwide. Owing to our limited understanding of …

Depression is a chronic, recurring, and serious mood disorder that afflicts up to 20% of the
global population. The monoamine hypothesis has dominated our understanding of the …

Recent data gathered from both in vitro and in vivo models of Major Depressive Disorder
(MDD) have indicated that microglia play an active role in modifying some of the most …

Emotion-related neural networks are regulated in part by the activity of glial cells, and glial
dysfunction can be directly related to emotional diseases such as depression. Here, we …

Depression has been widely accepted as a major psychiatric disease affecting nearly 350
million people worldwide. Research focus is now shifting from studying the extrinsic and …