Microglia are key players of the immune response in the central nervous system (CNS) and,
being the resident innate immune cells, they are responsible for the early control of …

Members of the Toll-like receptor (TLR) family play critical roles as regulators of innate and
adaptive immune responses. TLRs function by recognizing diverse molecular patterns on …

Innate immunity in the CNS depends primarily on the functions of glial cells, astrocytes and
microglia, which are important for the early control of pathogen replication and direct the …

Central nervous system (CNS) innate immunity plays essential roles in infections,
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …

Microglia cells function as sentinels for innate immunity in the central nervous system (CNS).
To perform this function, microglia express a diverse set of pattern recognition receptors …

The role of Toll-like receptors (TLRs) in the CNS is only starting to be uncovered. As in
peripheral organs, multiple TLRs are dynamically expressed. They are involved in mounting …

Microglia participate in all phases of the multiple sclerosis (MS) disease process. As
members of the innate immune system, these cells have evolved to respond to …

J. Neurochem.(2010) 114, 13–27. Abstract The responses of the brain to infection, ischemia
and trauma share remarkable similarities. These and other conditions of the CNS coordinate …

Recognition of pathogen-or damage-associated molecular patterns (PAMPs, DAMPs) by
innate Toll-like receptors (TLRs) is central to the activation of microglia (brain macrophages) …

Abstract Background Toll-like receptors (TLRs) enable innate immune cells to respond to
pathogen-and host-derived molecules. The central nervous system (CNS) exhibits most of …