In complex biological systems, small molecules often mediate microbe-microbe and microbe-
host interactions. Using a systematic approach, we identified 3,118 small-molecule …

INTRODUCTION The human microbiome has been correlated with several health and
disease conditions, but the molecular mechanisms underlying these correlations remain …

Covering: 2000 to 2017 Decades of research on human microbiota have revealed much of
their taxonomic diversity and established their direct link to health and disease. However …

Bacteria possess an amazing capacity to synthesize a diverse range of structurally complex,
bioactive natural products known as specialized (or secondary) metabolites. Many of these …

The mammalian gut has a remarkable abundance of microbes. These microbes have strong
potential to biosynthesize distinct metabolites that are promising drugs, and many more …

Antimicrobial resistance is considered a major public-health issue. Policies recommended
by the World Health Organization (WHO) include research on new antibiotics. No new class …

Human-associated microbes are the source of many bioactive microbial products (proteins
and metabolites) that play key functions both in human host pathways and in microbe …

Streptomyces bacteria are known for their prolific production of secondary metabolites, many
of which have been widely used in human medicine, agriculture and animal health. To guide …

The shrinking antibiotic development pipeline together with the global increase in antibiotic
resistant infections requires that new molecules with antimicrobial activity are developed …

Small molecules are the primary communication media of the microbial world. Recent
bioinformatic studies, exploring the biosynthetic gene clusters (BGCs) which produce many …