A series of autophagy-targeted antimetastatic clioquinol (CLQ) platinum (IV) conjugates
were designed and prepared by incorporating an autophagy activator CLQ into the platinum …

The development of novel anticancer drugs with antiproliferative and antimetastatic activities
is of great importance in the pharmaceutical field. Herein, a series of ligustrazine (LSZ) …

Here we report that three platinum (IV) prodrugs containing a tubulin inhibitor CA-4, as dual-
targeting platinum (IV) prodrug, were synthesized and evaluated for antitumor activity using …

Autophagy acts as a cytoprotective mechanism for malignant tumors, thus maintaining the
survival and promoting proliferation and metastasis of malignant tumors. Recent studies …

Although cisplatin has been widely used for clinical purposes, its application is limited due to
its obvious side effects. To mitigate the defects of cisplatin, here, six “multitarget prodrugs” …

Platinum-based anticancer drugs are one of the most widely used anticancer
chemotherapeutics in oncology. Lonidamine (LND) could increase the response of human …

Anticancer therapies reportedly promote pro-survival autophagy in cancer cells that confers
drug resistance, rationalizing the concept to combine autophagy inhibitors to increase their …

Autophagy is upregulated in response to metabolic stress, a hypoxic tumor
microenvironment, and therapeutic stress in various cancers and mediates tumor …

Abstract Background PI3K-Akt pathway activation and the expression of histone
deacetylases (HDACs) are highly increased in esophageal cancer, suggesting that …

Regulating autophagy to control the homeostatic recycling process of cancer cells is a
promising anticancer strategy. Golgi apparatus is a substrate of autophagy but the Golgi …