Maintenance of systemic homeostasis and the response to nutritional and environmental
challenges require the coordination of multiple organs and tissues. To respond to various …

Multidirectional interactions between metabolic organs in the periphery and the central
nervous system have evolved concomitantly with multicellular organisms to maintain whole …

Background Spatial compartmentalization of metabolic pathways within membrane-
separated organelles is key to the ability of eukaryotic cells to precisely regulate their …

Inter-tissue communication via secreted proteins has been established as a vital mechanism
for proper physiologic homeostasis. Here, we report a bioinformatics framework using a …

A thorough understanding of the mechanisms controlling energy homeostasis is needed to
prevent and treat metabolic morbidities. While the contribution of organs such as the liver …

Background The gut-brain axis, which mediates the bi-directional communication between
the gastrointestinal system and the central nervous system (CNS), plays a fundamental role …

Systemic metabolism has to be constantly adjusted to the variance of food intake and even
be prepared for anticipated changes in nutrient availability. Therefore, the brain integrates …

The proper functioning of the pathways that are involved in the sensing and management of
nutrients is central to metabolic homeostasis and is therefore among the most fundamental …

A highly complex network of organ communication plays a key role in regulating metabolic
homeostasis, specifically due to the modulation of the insulin signaling machinery. As a …

Metabolite sensing is one of the most fundamental biological processes. During evolution,
multilayered mechanisms developed to sense fluctuations in a wide spectrum of …