Sulbactam/durlobactam: first approval
SJ Keam - Drugs, 2023 - Springer
Abstract Sulbactam/durlobactam (XACDURO®), is a co-packaged antibacterial product that
has been developed by Entasis Therapeutics Inc. for the treatment of infections caused by …
has been developed by Entasis Therapeutics Inc. for the treatment of infections caused by …
The pharmacokinetics/pharmacodynamic relationship of durlobactam in combination with sulbactam in in vitro and in vivo infection model systems versus …
JP O'Donnell, SM Bhavnani - Clinical Infectious Diseases, 2023 - academic.oup.com
Sulbactam-durlobactam is a β-lactam/β-lactamase inhibitor combination currently in
development for the treatment of infections caused by Acinetobacter, including multidrug …
development for the treatment of infections caused by Acinetobacter, including multidrug …
In Vitro Activity of Sulbactam-Durlobactam against Acinetobacter baumannii-calcoaceticus Complex Isolates Collected Globally in 2016 and 2017
SM McLeod, SH Moussa, MA Hackel… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
Acinetobacter baumannii-calcoaceticus complex (ABC) organisms cause severe infections
that are difficult to treat due to preexisting antibiotic resistance. Sulbactam-durlobactam …
that are difficult to treat due to preexisting antibiotic resistance. Sulbactam-durlobactam …
Durlobactam, a Broad-Spectrum Serine β-lactamase Inhibitor, Restores Sulbactam Activity Against Acinetobacter Species
KM Papp-Wallace, SM McLeod… - Clinical Infectious …, 2023 - academic.oup.com
Sulbactam-durlobactam is a pathogen-targeted β-lactam/β-lactamase inhibitor combination
in late-stage development for the treatment of Acinetobacter infections, including those …
in late-stage development for the treatment of Acinetobacter infections, including those …
In vivo dose response and efficacy of the β-lactamase inhibitor, durlobactam, in combination with sulbactam against the Acinetobacter baumannii-calcoaceticus …
J O'Donnell, A Tanudra, A Chen… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Multi-drug resistant (MDR) Acinetobacter baumannii is emerging as a pathogen of
increasing prevalence and concern. Infections associated with this Gram-negative pathogen …
increasing prevalence and concern. Infections associated with this Gram-negative pathogen …
In Vitro Activity of Sulbactam-Durlobactam against Global Isolates of Acinetobacter baumannii-calcoaceticus Complex Collected from 2016 to 2021
JA Karlowsky, MA Hackel, SM McLeod… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Sulbactam-durlobactam is a β-lactam-β-lactamase inhibitor combination designed to treat
serious Acinetobacter baumannii-calcoaceticus complex (ABC) infections, including …
serious Acinetobacter baumannii-calcoaceticus complex (ABC) infections, including …
In vitro pharmacokinetics/pharmacodynamics of the β-lactamase inhibitor, durlobactam, in combination with sulbactam against Acinetobacter baumannii-calcoaceticus …
J O'Donnell, A Tanudra, A Chen, AA Miller… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Infections caused by Acinetobacter baumannii are increasingly multidrug resistant and
associated with high rates of morbidity and mortality. Sulbactam is a β-lactamase inhibitor …
associated with high rates of morbidity and mortality. Sulbactam is a β-lactamase inhibitor …
Molecular drivers of resistance to sulbactam-durlobactam in contemporary clinical isolates of Acinetobacter baumannii
SH Moussa, AB Shapiro, SM McLeod… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Acinetobacter baumannii-calcoaceticus complex (ABC) causes severe infections that are
difficult to treat due to pre-existing antibiotic resistance. Sulbactam-durlobactam (SUL-DUR) …
difficult to treat due to pre-existing antibiotic resistance. Sulbactam-durlobactam (SUL-DUR) …
Activity of Sulbactam-Durlobactam and Comparators Against a National Collection of Carbapenem-Resistant Acinetobacter baumannii Isolates From Greece
D Petropoulou, M Siopi, S Vourli… - Frontiers in Cellular and …, 2022 - frontiersin.org
Background Acinetobacter baumannii is a leading cause of healthcare-associated infections
worldwide, due to both its persistence in the hospital setting and ability to acquire high levels …
worldwide, due to both its persistence in the hospital setting and ability to acquire high levels …
A New Twist: The Combination of Sulbactam/Avibactam Enhances Sulbactam Activity against Carbapenem-Resistant Acinetobacter baumannii (CRAB) Isolates
F Pasteran, J Cedano, M Baez, E Albornoz… - Antibiotics, 2021 - mdpi.com
An increasing number of untreatable infections are recorded every year. Many studies have
focused their efforts on developing new β-lactamase inhibitors to treat multi-drug resistant …
focused their efforts on developing new β-lactamase inhibitors to treat multi-drug resistant …