Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and
paracrine factors, to signaling molecules on neighboring cells. It is of great importance that …

Recent years have witnessed tremendous growth in the epidermal growth factor (EGF)
family of peptide growth factors and the ErbB family of tyrosine kinases, the receptors for …

The ErbB/HER protein-tyrosine kinases, which include the epidermal growth factor receptor,
consist of a growth-factor-binding ectodomain, a single transmembrane segment, an …

Polypeptide growth factors regulate cellular growth by stimulating the intrinsic protein
tyrosine kinase activities of their specific cell surface receptors. The receptor for epidermal …

The four members of the ErbB family of receptor tyrosine kinases (RTKs) mediate a variety of
cellular responses to epidermal growth factor (EGF)-like growth factors, and serve as a …

Publisher Summary This chapter focuses on the role played by ErbB receptors in cancer
progression. Cancer patients, whose tumors have alterations in ErbB1 or ErbB2, tend to …

The epidermal growth factor (EGF)-related peptides bind the ErbB receptors, inducing the
formation of different homo-and heterodimers. Receptor dimerization promotes activation of …

Publisher Summary Carcinoma, cancer of epithelial cells, is a major cause of morbidity and
mortality. Clonal fixation and propagation of oncogenic genetic changes, sporadically …

The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …

The epidermal growth factor (EGF)-like family of growth factors elicits cellular responses by
stimulating the dimerization, autophosphorylation, and tyrosine kinase activities of the ErbB …