While the application of cryogenic electron microscopy (cryo-EM) to helical polymers in
biology has a long history, due to the huge number of helical macromolecular assemblies in …

The application of cryogenic transmission electron microscopy (cryo-TEM) in the study of
molecular self-assembly of amphiphilic macromolecules, lipid/surfactants, peptides, and …

Background Since the introduction of what became today's standard for cryo-embedding of
biological macromolecules at native conditions more than 30 years ago, techniques and …

Supramolecular and covalent polymers share multiple structural effects such as chiral
amplification, helical inversion, sergeants and soldiers, or majority rules, among others …

Cryo‐electron microscopy (cryo‐EM) is a structural biological method that is used to
determine the 3D structures of biomacromolecules. After years of development, cryo‐EM has …

There is growing interest in the design of synthetic molecules that are able to self‐assemble
into a polymeric chain with compact helical conformations, which is analogous to the folded …

Numerous instances can be seen in evolution in which protein quaternary structures have
diverged while the sequences of the building blocks have remained fairly conserved …

Properties of soft crystalline materials such as synthetic polymers are governed by locations
of constituent atoms. Determining atomic-scale structures in these materials is difficult …

Highlights•Near-atomic resolution cryo-EM structures of challenging targets can now be
obtained.•Advances in sample preparation increases chance of high-resolution structure …

One of the most intriguing dissymmetric shapes is the helix. It was developed in natural
systems in the early stages of evolution and used as the structural motif for the molecules of …