Interleukin‐33 in allergy

T Ohno, H Morita, K Arae, K Matsumoto, S Nakae - Allergy, 2012 - Wiley Online Library
Abstract Interleukin‐33 (IL‐33) is a member of the IL‐1 cytokine family, which includes IL‐1
and IL‐18, and is considered to be important for host defense against nematodes by …

IL‐33: a tissue derived cytokine pathway involved in allergic inflammation and asthma

DE Smith - Clinical & Experimental Allergy, 2010 - Wiley Online Library
Besides classic T cell‐derived T‐helper type 2 (Th2) cytokines such as IL‐4, IL‐5 and IL‐13,
tissue‐produced cytokines such as thymic stromal lymphopoietin, IL‐25 and IL‐33 are now …

Role of interleukin-33 in innate-type immune cells in allergy

S Nakae, H Morita, T Ohno, K Arae, K Matsumoto… - Allergology …, 2013 - Elsevier
ABSTRACT Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is preferentially and
constitutively expressed in epithelial cells, and it is especially localized in the cells' nucleus …

IL‐33: biological properties, functions, and roles in airway disease

LY Drake, H Kita - Immunological reviews, 2017 - Wiley Online Library
Summary Interleukin (IL)‐33 is a key cytokine involved in type 2 immunity and allergic
airway diseases. Abundantly expressed in lung epithelial cells, IL‐33 plays critical roles in …

Interleukin‐33 amplifies I g E synthesis and triggers mast cell degranulation via interleukin‐4 in naïve mice

M Komai‐Koma, F Brombacher, PN Pushparaj… - Allergy, 2012 - Wiley Online Library
Background The regulation and function of I g E in healthy individuals and in antigen‐naïve
animals is not well understood. IL‐33 administration increases serum I g E in mice with …

Interleukin‐33 (IL‐33): a nuclear cytokine from the IL‐1 family

C Cayrol, JP Girard - Immunological reviews, 2018 - Wiley Online Library
Summary Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family
abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both …

[HTML][HTML] Interleukin-33: its emerging role in allergic diseases

W Ding, GL Zou, W Zhang, XN Lai, HW Chen, LX Xiong - Molecules, 2018 - mdpi.com
Allergic diseases, which include asthma, allergic rhinitis (AR), chronic rhinosinusitis (CRS),
atopic dermatitis (AD), food allergy (FA), allergic keratoconjunctivitis, seriously affect the …

Interleukin-13 in asthma

M Wills-Karp, M Chiaramonte - Current opinion in pulmonary …, 2003 - journals.lww.com
Some time ago, the Th2 cytokine, interleukin (IL)-13, was identified as a critical regulator of
the allergic response. Initial studies in animal models of disease provided compelling …

Interleukin‐33 in the developing lung—Roles in asthma and infection

K Johansson, HJ McSorley - Pediatric Allergy and Immunology, 2019 - Wiley Online Library
It has become increasingly clear that interleukin‐33 (IL‐33) plays a crucial role in initiation of
type 2 immunity. The last decade of intense research has uncovered multiple mechanisms …

[HTML][HTML] The role of IL-33 and mast cells in allergy and inflammation

R Saluja, M Khan, MK Church, M Maurer - Clinical and translational allergy, 2015 - Springer
Abstract Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) cytokine family. It is
preferentially and constitutively expressed in different structural cells such as epithelial cells …