Ethnopharmacological relevance Among amphibians, 15 of the 47 species reported to be
used in traditional medicines belong to the family Bufonidae, which demonstrates their …

Amphibian skin has been the source of a wide variety of biologically active substances, but
less than one-third of the known genera of amphibians have been probed for such active …

Cutaneous granular glands are a shared character of adult amphibians, including
caecilians, and are thought to be the source of most biologically active compounds in …

Amphibians have been occupying a wide range of habitats since they evolved around 363
million-years-ago. Along with legs and lungs, skin played an important role in survival of …

Amphibian skin has provided a wide range of biologically active alkaloids. During the past
30 years, over 400 alkaloids of over 20 structural classes have been detected. These …

A remarkably diverse array of biologically active compounds occurs in amphibian skin [1].
These include biogenic amines and derivatives thereof, peptides, proteins, bufadienolides …

A remarkable diversity of bioactive lipophilic alkaloids is present in the skin of poison frogs
and toads worldwide. Originally discovered in neotropical dendrobatid frogs, these alkaloids …

Ethnopharmacological relevance Toads known as “cururú”(Rhinella schneideri) have been
used in the Brazilian Pantanal and Paraguayan Chaco wetlands to treat erysipelas and …

Bufadienolides are the main active compounds in the Bufonidae family of frogs. Recent
studies have demonstrated cytotoxic and/or antitumor activity in these molecules. A HPLC …

The red-belly toads (Melanophryniscus) of southern South America secrete defensive
alkaloids from dermal granular glands. To date, all information on Melanophryniscus …