Iron is a biometal involved in many physiological processes that are essential for life. Iron
metabolism is a complex and tightly regulated process both at the systemic and cellular …

Iron is an essential element for numerous fundamental biological processes, including
erythropoiesis; however, in large quantities and when unbound, iron can be highly toxic to …

Iron is essential for life because it is indispensable for several biological reactions, such as
oxygen transport, DNA synthesis, and cell proliferation. Over the past few years, our …

Iron is a vitally important element in mammalian metabolism because of its unsurpassed
versatility as a biologic catalyst. However, when not appropriately shielded or when present …

Divalent metal-iron transporter 1 (DMT1) is a mammalian iron transporter encoded by the
SLC11A2 gene. DMT1 has a vital role in iron homeostasis by mediating iron uptake in the …

Hereditary dyserythropoietic anemias, or congenital dyserythropoietic anemias (CDAs), are
rare disorders disrupting normal erythroid lineage development, resulting in ineffective …

Background: Anemia affects~ 25% of the world population and is frequently caused by iron
deficiency as a consequence of malnutrition or inflammation. Only in rare cases anemia is …

Anemia is defined by a deficiency of hemoglobin, an iron-rich protein that binds oxygen in
the blood. It can be due to multiple causes, either acquired or genetic. Alterations of genes …

TMPRSS6 variants that affect protein function result in impaired matriptase‐2 function and
consequently uninhibited hepcidin production, leading to iron refractory iron deficiency …

Advances in iron metabolism have allowed a novel classification of iron disorders and to
identify previously unknown diseases. These disorders include genetic iron overload …