Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumor, with
no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small …

Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical
screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated …

Neuroblastoma is a frequently lethal childhood tumor in which MYC gene deregulation,
commonly as MYCN amplification, portends poor outcome. Identifying the requisite …

Diffuse intrinsic pontine glioma (DIPG) is a high-grade glioma that originates in the pons and
is seen exclusively in children. Despite numerous efforts to improve treatment, DIPG remains …

Diffuse midline glioma (DMG) is a uniformly fatal pediatric cancer driven by oncohistones
that do not readily lend themselves to drug development. To identify druggable targets for …

Neuroblastoma (NB) is associated with MYCN oncogene amplification occurring in
approximately 30% of NBs and is associated with poor prognosis. MYCN is linked to a …

Background: Diffuse Intrinsic Pontine Glioma (DIPG) is the leading cause of brain tumor-
related death in children, with median survival of less than one year. Despite decades of …

Neuroblastoma is a childhood tumor in which MYC oncogenes are commonly activated to
drive tumor progression. Survival for children with high-risk neuroblastoma remains poor …

Glioblastoma is characterized by the robust infiltration of immunosuppressive tumor-
associated myeloid cells (TAMCs). It is not fully understood how TAMCs survive in the acidic …

Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brainstem tumor
characterized by rapid and uniform patient demise. A heterozygous point mutation of histone …