In many organisms, metabolite interconversion at the phosphoenolpyruvate (PEP)–pyruvate–
oxaloacetate node involves a structurally entangled set of reactions that interconnects the …

At the junction between the glycolysis and the tricarboxylic acid cycle—as well as various
other metabolic pathways—lies the phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate …

Complete oxidation of carbohydrates to CO 2 is considered to be the exclusive property of
the ubiquitous tricarboxylic acid cycle, the central process in cellular energy metabolism of …

The structurally conserved and ubiquitous pathways of central carbon metabolism provide
building blocks and cofactors for the biosynthesis of cellular macromolecules. The relative …

Two branches of the phosphoenolpyruvate-phosphotransferase system (PTS) operate in the
soil bacterium Pseudomonas putida KT2440. One branch encompasses a complete set of …

The C 3-C 4 metabolite interconversion at the anaplerotic node in many microorganisms
involves a complex set of reactions. C 3 carboxylation to oxaloacetate can originate from …

Carbon catabolite repression (CCR) is the paradigm of cellular regulation. CCR happens
when bacteria are exposed to two or more carbon sources and one of them is preferentially …

What defines central carbon metabolism? The classic textbook scheme of central
metabolism includes the Embden-Meyerhof-Parnas (EMP) pathway of glycolysis, the …

Growth of Corynebacterium glutamicum on mixtures of the carbon sources glucose and
acetate is shown to be distinct from growth on either substrate alone. The organism showed …

Overflow metabolism is well known for yeast, bacteria and mammalian cells. It typically
occurs under glucose excess conditions and is characterized by excretions of by-products …