The growth of knowledge in the field of the pharmacokinetics of prednisolone/prednisone
has been slow for several reasons. First, convenient and specific methods for measuring …

Prednisone and prednisolone are used in a wide variety of diseases. The two compounds
are metabolically interconvertible; prednisolone is assumed to be the pharmacologically …

I. Introduction T HE PHARMACOLOGICAL response (dynamics) to corticosteroids is
determined by the affinity of these steroids to specific receptors at the target organ and by …

Kinetic data for prednisolone and prednisone have been determined following oral
administration of prednisolone over a dosage range of 5 to 200 mg in 43 subjects …

Six healthy male volunteers were given 5, 20, and 50 mg of oral prednisone and 5, 20, and
40 mg doses of intravenous prednisolone. Plasma and urine concentrations of prednisone …

The pharmacokinetics of prednisolone elimination have been studied in both arthritic
patients and normal volunteers using tritiated prednisolone alone, and in conjunction with …

The pharmacokinetics of prednisone and prednisolone was examined in 12 healthy male
subjects to assess the bioavailability and the parameters of reversible metabolism between …

Limited information is available on the pharmacokinetics and bioavailability of prednisone
and prednisolone in patients with different disease states. This is partly due to difficulty in …

The pharmacokinetics of prednisolone after oral and intravenous administration of 10 and
20 mg have been studied. Serum protein binding of prednisolone was also measured after …

The disposition and plasma binding of methylprednisolone were examined in seven normal
volunteers following the administration of 5, 20 and 40 mg of intravenous …