Role of CD4 and CD8 in T cell activation and differentiation
MC Miceli, JR Parnes - Advances in immunology, 1993 - Elsevier
Publisher Summary This chapter summarizes the role of CD4 and CD8 in both T cell
activation and differentiation. CD4 and CD8 are cell surface glycoproteins expressed on T …
activation and differentiation. CD4 and CD8 are cell surface glycoproteins expressed on T …
The lack of CD8α cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T …
WP Fung‐Leung, MC Louie, A Limmer… - European journal of …, 1993 - Wiley Online Library
The glycoprotein CD8 is believed to play an important role in the maturation and function of
MHC class I‐restricted T lymphocytes. CD8 has been proposed to function as a co‐receptor …
MHC class I‐restricted T lymphocytes. CD8 has been proposed to function as a co‐receptor …
A structural view of CD4 and CD8
DJ Leahy - The FASEB journal, 1995 - Wiley Online Library
CD4 and CD8 are cell‐surface glycoproteins that participate in molecular complexes
involved in both T cell development and antigen recognition by T cells, CD4 and CDS …
involved in both T cell development and antigen recognition by T cells, CD4 and CDS …
Molecular biology and function of CD4 and CD8
JR Parnes - Advances in immunology, 1989 - Elsevier
Publisher Summary Progress on the understanding of CD4 and CD8 function has
proceeded at an accelerating rate in the recent years. There are still many open questions …
proceeded at an accelerating rate in the recent years. There are still many open questions …
Multiple roles of CD4 and CD8 in T cell activation
GA Koretzky - The journal of immunology, 2010 - journals.aai.org
The field of T cell biology was ushered in with a series of discoveries in the 1960s
demonstrating that the thymus was not a vestigial organ lacking important biologic function …
demonstrating that the thymus was not a vestigial organ lacking important biologic function …
[引用][C] T‐lymphocyte activation: the biology and function of CD2 and CD4
BE Bierer, SJ Burakoff - Immunological reviews, 1989 - Wiley Online Library
T lymphocytes are derived from hematopoietic stem cells which migrate from the bone
marrow to colotiize the thymus. Within the thymic microenvirotiment, T cells differentiate to …
marrow to colotiize the thymus. Within the thymic microenvirotiment, T cells differentiate to …
Resting and activated T cells display different requirements for CD8 molecules.
Clonotype-positive (1B2+) T cells from 2C T cell receptor (TCR) transgenic mice were used
to define the role of CD8 molecules in the induction phase vs. the effector phase of the …
to define the role of CD8 molecules in the induction phase vs. the effector phase of the …
The roles of CD4 and CD8 in T cell activation.
MC Miceli, JR Parnes - Seminars in immunology, 1991 - europepmc.org
CD4 and CD8 T cell surface molecules play a role in T cell recognition and activation by
binding to their respective class II and class I major histocompatibility complex (MHC) …
binding to their respective class II and class I major histocompatibility complex (MHC) …
CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity
HS Azzam, A Grinberg, K Lui, H Shen… - The Journal of …, 1998 - rupress.org
Recent data indicate that the cell surface glycoprotein CD5 functions as a negative regulator
of T cell receptor (TCR)-mediated signaling. In this study, we examined the regulation of …
of T cell receptor (TCR)-mediated signaling. In this study, we examined the regulation of …
The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.
Thymocytes must bind major histocompatibility complex (MHC) proteins on thymic epithelial
cells in order to mature into either CD8+ cytotoxic T cells or CD4+ helper T cells. Thymic …
cells in order to mature into either CD8+ cytotoxic T cells or CD4+ helper T cells. Thymic …