We show that R-Ras, a small GTPase of the Ras family, is essential for the establishment of
mature, functional blood vessels in tumors. The genetic disruption of R-Ras severely …

R-Ras is a small GTPase of the Ras family that regulates cell survival and integrin activity.
Despite a number of in vitro studies, the in vivo function of R-Ras remains unclear. Here, we …

Since the identification of R-Ras, which is the first Ras-related GTPase isolated based on
sequence similarity to the classical RAS oncogene, more than 160 members of the Ras …

Mutations in the small GTPase R-Ras that promote constitutive activation of this signaling
molecule have been observed in a variety of invasive cancer cell types. We previously …

The Ras family GTPase, R-Ras, elicits important integrin-dependent cellular behaviors such
as adhesion, spreading and migration. While oncogenic Ras GTPases and R-Ras share …

R-Ras is a Ras family small GTPase that is highly expressed in mature functional blood
vessels in normal tissues. It inhibits pathological angiogenesis and promotes vessel …

The Ras oncoproteins are membrane-associated molecular switches that function to
transduce extracellular signals to a panoply of intracellular response mechanisms …

Abnormal angiogenesis is associated with a broad range of medical conditions, including
cancer. The formation of neovasculature with functionally defective blood vessels …

The small GTPase Ras family regulates a variety of cell functions including proliferation and
differentiation. Here we have identified novel Ras members, human Di-Ras1 and Di-Ras2 …

Abstract Background: The small GTPase R-Ras displays a less potent transforming activity
than the closely related Ras oncogene products. Although R-Ras has been reported to …