Multiphoton excitation fluorescence microscopy (MPM) can image certain molecular
processes in vivo. In the eye, fluorescent retinyl esters in subcellular structures called …

Two-photon excitation microscopy can image retinal molecular processes in vivo.
Intrinsically fluorescent retinyl esters in subcellular structures called retinosomes are an …

Purpose.: Noninvasive two-photon imaging of a living mammalian eye can reveal details of
molecular processes in the retina and RPE. Retinyl esters and all-trans-retinal condensation …

Purpose: Two-photon excited fluorescence (TPEF) imaging has potential as a functional tool
for tracking visual pigment regeneration in the living eye. Previous studies have shown that …

Visual sensation in vertebrates is triggered when light strikes retinal photoreceptor cells
causing photoisomerization of the rhodopsin chromophore 11-cis-retinal to all-trans-retinal …

High-resolution imaging techniques capable of detecting identifiable endogenous
fluorophores in the eye along with genetic testing will dramatically improve diagnostic …

Two-photon microscopy allows visualization of subcellular structures in the living animal
retina. In previously reported experiments it was necessary to apply a contact lens to each …

Purpose: The retinoid cycle maintains vision by regenerating bleached visual pigment
through metabolic events, the kinetics of which have been difficult to characterize in vivo …

Cell type–specific green fluorescent protein (GFP) expression in the retina has been
achieved in an expanding repertoire of transgenic mouse lines, which are valuable tools for …

To assess serial section block-face scanning electron microscopy (SBFSEM) for retinal
pigment epithelium (RPE) ultrastructure, we determined the number and distribution within …