Epithelial Ovarian cancer (EOC) is the deadliest gynecologic malignancy and represents the
fifth leading cause of all cancer-related deaths in women. The majority of patients are …

Cancer cells undergo alterations in lipid metabolism to support their high energy needs,
tumorigenesis and evade an anti-tumor immune response. Alterations in fatty acid …

Simple Summary Around 4% of cancer deaths in the world was associated to ovarian cancer
(OC), making it the eighth most common cause of death in women. Increasing evidence …

Lysophosphatidic acid (LPA), a bioactive phospholipid, stimulates survival, proliferation,
adhesion, migration and invasion of ovarian cancer cells through the activation of G-protein …

This review highlights recent advances in the understanding of the relevance of altered lipid
metabolic pathways contributing to the poor prognosis of high grade serous ovarian cancer …

Cholesterol is an essential substance in mammalian cells, and cholesterol metabolism plays
crucial roles in multiple biological functions. Dysregulated cholesterol metabolism is a …

Ovarian cancer is associated with limited overall survival, due to problems in early detection
and therapy. Membrane ion channels have been proposed to play a significant, concerted …

Ovarian cancer is the most malignant gynecological tumor. Previous studies have reported
that metabolic alterations resulting from deregulated lipid metabolism promote ovarian …

As one of the important cancer hallmarks, metabolism reprogramming, including lipid
metabolism alterations, occurs in tumor cells and the tumor microenvironment (TME). It plays …

Arachidonic acid (AA) is a polyunsaturated fatty acid present at high concentrations in the
ovarian cancer (OC) microenvironment and associated with a poor clinical outcome. In the …