GABA-modulating bacteria of the human gut microbiota

P Strandwitz, KH Kim, D Terekhova, JK Liu… - Nature …, 2019 - nature.com
The gut microbiota affects many important host functions, including the immune response
and the nervous system. However, while substantial progress has been made in growing …

GABA Production by Human Intestinal Bacteroides spp.: Prevalence, Regulation, and Role in Acid Stress Tolerance

N Otaru, K Ye, D Mujezinovic, L Berchtold… - Frontiers in …, 2021 - frontiersin.org
The high neuroactive potential of metabolites produced by gut microbes has gained traction
over the last few years, with metagenomic-based studies suggesting an important role of …

The neuroactive potential of the human gut microbiota in quality of life and depression

M Valles-Colomer, G Falony, Y Darzi… - Nature …, 2019 - nature.com
The relationship between gut microbial metabolism and mental health is one of the most
intriguing and controversial topics in microbiome research. Bidirectional microbiota–gut …

[HTML][HTML] The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice

Y Fan, RK Støving, S Berreira Ibraim… - Nature …, 2023 - nature.com
Anorexia nervosa (AN) is an eating disorder with a high mortality. About 95% of cases are
women and it has a population prevalence of about 1%, but evidence-based treatment is …

A high-resolution transcriptome map identifies small RNA regulation of metabolism in the gut microbe Bacteroides thetaiotaomicron

D Ryan, L Jenniches, S Reichardt, L Barquist… - Nature …, 2020 - nature.com
Bacteria of the genus Bacteroides are common members of the human intestinal microbiota
and important degraders of polysaccharides in the gut. Among them, the species …

An insider's perspective: Bacteroides as a window into the microbiome

AG Wexler, AL Goodman - Nature microbiology, 2017 - nature.com
Over the last decade, our appreciation for the contribution of resident gut microorganisms—
the gut microbiota—to human health has surged. However, progress is limited by the sheer …

Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders

J Yang, P Zheng, Y Li, J Wu, X Tan, J Zhou, Z Sun… - Science …, 2020 - science.org
Gut microbiome disturbances have been implicated in major depressive disorder (MDD).
However, little is known about how the gut virome, microbiome, and fecal metabolome …

Bifidobacterium adolescentis as a key member of the human gut microbiota in the production of GABA

S Duranti, L Ruiz, GA Lugli, H Tames, C Milani… - Scientific reports, 2020 - nature.com
Gamma aminobutyric acid (GABA) is the principal inhibitory neurotransmitter playing a key
role in anxiety and depression disorders in mammals. Recent studies revealed that …

A metabolomics pipeline for the mechanistic interrogation of the gut microbiome

S Han, W Van Treuren, CR Fischer, BD Merrill… - Nature, 2021 - nature.com
Gut microorganisms modulate host phenotypes and are associated with numerous health
effects in humans, ranging from host responses to cancer immunotherapy to metabolic …

γ‐Aminobutyric acid production by culturable bacteria from the human intestine

E Barrett, RP Ross, PW O'Toole… - Journal of applied …, 2012 - academic.oup.com
Aims To assess the ability of human intestinally derived strains of Lactobacillus and
Bifidobacterium to produce γ‐aminobutyric acid (GABA). Methods and Results Strains of …