The glomerulus is a compact cluster of capillaries responsible for blood filtration and
initiating urine production in the renal nephrons. A trilaminar structure in the capillary wall …

Background The human glomerulus is the primary filtration unit of the kidney, and contains
the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers-the …

In vitro investigation of a glomerular filtration barrier (GFB) remains difficult because of the
inability to mimic its specialized structure, although various kidney diseases are …

A glomerulus is the network of capillaries that resides in the Bowman's capsule that
functions as a filtration unit of kidney. The glomerular function ensures that essential plasma …

The epithelial filtration slit is a crucial component of the glomerular capillary membrane,
which is essential for maintaining glomerular filtration function. Though chronic kidney …

The use of biomimetic models of the glomerulus has the potential to improve our
understanding of the pathogenesis of kidney diseases and to enable progress in …

Crosstalk between glomerular endothelial cells and glomerular epithelial cells (podocytes)
is increasingly becoming apparent as a crucial mechanism to maintain the integrity of the …

The glomerular filtration barrier is a highly specialized blood filtration interface that displays
a high conductance to small and midsized solutes in plasma but retains relative …

Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …