Focused Ultrasound (FUS) in combination with gaseous microbubbles has emerged as a
potential new means of effective drug delivery to the brain. Recent research has shown that …

The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …

The range of therapeutic treatment options for central nervous system (CNS) diseases is
greatly limited by the blood-brain barrier (BBB). While a variety of strategies to circumvent …

The blood–brain barrier (BBB) protects the central nervous system (CNS) from invasive
pathogens and maintains the homeostasis of the brain. Penetrating the BBB has been a …

Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases.
Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently …

The physiology of the vasculature in the central nervous system (CNS), which includes the
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …

Focused ultrasound (FUS) combined with microbubbles is a non-invasive method for
targeted, reversible disruption of the blood–brain barrier (FUS-BBB opening). This approach …

The use of focused ultrasound (FUS) with microbubbles has been proven to induce transient
blood–brain barrier opening (BBB-opening). However, FUS-induced inertial cavitation of …

Microbubbles (MBs) serve as a critical catalyst to amplify local cavitation in CNS capillary
lumen to facilitate focused ultrasound (FUS) to transiently open the blood-brain barrier …

Despite recent advances in blood–brain barrier (BBB) research, it remains a significant
hurdle for the pharmaceutical treatment of brain diseases. Focused ultrasound (FUS) is one …