Chronic pain often predicts the onset of psychological distress. Symptoms including anxiety
and depression after pain chronification reportedly are caused by brain remodeling …

Application of functional imaging techniques to animal models is vital to understand pain
mechanisms, but is often confounded by the need to limit movement artefacts with …

Chronic pain is a major health problem, affecting 10–30% of the population in developed
countries. While chronic pain is defined as “a persistent complaint of pain lasting for more …

Manganese ion (Mn2+) was used as a paramagnetic contrast agent in T1-weighted
magnetic resonance imaging (MRI) images. They enter neural cells though voltage-gated …

Neuroimaging of pain in animals allows us to better understand mechanisms of pain
processing and modulation. In this review, we discuss recently published brain imaging …

The ability of divalent manganese to enter neurons via calcium channels makes manganese
an excellent MRI contrast agent for the imaging of nociception, the afferent neuronal …

MR-based brain imaging technologies provide a suite of functional and structural metrics
that can be used to test hypotheses about the CNS mechanisms underlying pain perception …

Recent use of manganese-enhanced MRI (MEMRI) to assess the neural circuitry involved in
autonomic and somatosensory paradigms has been promising. The current study addresses …

In human conditions, chronic pain is associated with widespread anatomical changes in the
brain. Nevertheless, little is known about the time course of these changes or the …

Peripheral neuropathy often manifests clinically with symptoms of mechanical and cold
allodynia. However, the neuroplastic changes associated with peripheral neuropathic pain …