Drug discovery from marine natural products has experienced a revival since the beginning
of this century. To be successful in this field, rapid dereplication (identification of already …

Natural products are an indispensable source for drug discovery. The major challenge for
exploiting this evolutionary optimized pool of potential lead structures is the fast and reliable …

The discovery of novel and/or new bioactive natural products from biota sources is often
confounded by the reisolation of known natural products. Dereplication strategies that …

Complete structural elucidation of natural products is commonly performed by nuclear
magnetic resonance spectroscopy (NMR), but annotating compounds to most likely …

The development of new drugs will certainly benefit from an ever improving knowledge of
the living beings chemistry. However, identification of drugable molecules within the …

Natural products are the most consistently successful source of drug leads. The rapid
identification of known compounds from natural product extracts, or 'dereplication', is an …

Plants represent an extraordinary reservoir of novel molecules and there is currently a
resurgence of interest in the vegetable kingdom as a possible source of new lead …

The rapid identification of known or undesirable compounds from natural products extracts—
“dereplication”—is an important step in an efficiently run natural products discovery program …

Thanks to the important advances registered over the last decade in analytical techniques,
profiling methods for the analysis of crude extracts from plant origin or from other biological …

Highlights•Marine natural products have been proved to be promising drug sources.•New
tools make the utility of “dark matter” possible.•Current developed dereplication strategies …