Complex brain disorders are highly heritable and arise from a complex polygenic risk
architecture. Many disease-associated loci are found in non-coding regions that house …

The genetic architecture of each individual comprises common and rare variants that, acting
alone and in combination, confer risk of disease. The cell-type-specific and/or context …

Neurodegenerative, neurodevelopmental and neuropsychiatric disorders are among the
greatest public health challenges, as many lack disease-modifying treatments. A major …

Modulation of transcription, either synthetic activation or repression, via dCas9-fusion
proteins is a relatively new methodology with the potential to facilitate high-throughput up-or …

CRISPR/Cas9-based functional genomics have transformed our ability to elucidate
mammalian cell biology. However, most previous CRISPR-based screens were conducted …

Studying the function of common genetic variants in primary human tissues and during
development is challenging. To address this, we use an efficient multiplexing strategy to …

CRISPR/Cas9 technology has transformed our ability to manipulate the genome and
epigenome, from efficient genomic editing to targeted localization of effectors to specific loci …

Human pluripotent stem cells (hPSCs) generate a variety of disease-relevant cells that can
be used to improve the translation of preclinical research. Despite the potential of hPSCs …

Microglia are emerging as key drivers of neurological diseases. However, we lack a
systematic understanding of the underlying mechanisms. Here, we present a screening …

Abstract Development of effective therapeutics for neurological disorders has historically
been challenging partly because of lack of accurate model systems in which to investigate …