Introduction Liver fibrosis is a life-threatening pathological anomaly which usually evolves
into advanced liver cirrhosis and hepatocellular carcinoma although limited therapeutic …

Mitochondria lie at the heart of innate immunity, and aberrant mitochondrial activity
contributes to immune activation and chronic inflammatory diseases, including liver cancers …

Ferroptosis is an iron-dependent programmed necrosis characterized by glutathione (GSH)
depletion and lipid peroxidation (LPO). Armed with both the pro-and antiferroptosis …

Hepatocellular death is a sensitive parameter for detecting acute liver injury (ALI) of toxic,
viral, metabolic, and autoimmune origin. Ferroptosis has recently been implicated in carbon …

Metabolic-associated fatty liver disease (MAFLD), which is previously known as non-
alcoholic fatty liver disease (NAFLD), represents a major health concern worldwide with …

Mitochondrial autophagy (mitophagy) is the selective clearance of damaged or incomplete
mitochondria by autophagy, which is critical for the functional integrity of the entire …

Ferroptosis is a recently discovered form of programmed cell death, but its regulatory
mechanisms remain poorly understood. Here, we show that the RNA-binding protein …

Fluoride can induce hepatotoxicity, but the mechanisms responsible are yet to be
investigated. This study sought to investigate the role and mechanism of mitochondrial …

Characterized by excessive iron accumulation and lipid peroxidation, ferroptosis is a novel
form of iron-dependent cell death, which is morphologically, genetically, and biochemically …

Highlights•Matrine (MT) is potentially toxic to the liver.•The hepatotoxic effects of MT involve
disruption of iron homeostasis.•The hepatotoxicity of MT involves Nrf2/GPX4 system …