Genistein protects prostate cells against hydrogen peroxide-induced DNA damage and induces expression of genes involved in the defence against oxidative stress

M Raschke, IR Rowland, PJ Magee… - …, 2006 - academic.oup.com
Prostate cancer is one of the most frequent cancer types in Western societies and
predominately occurs in the elderly male. The strong age-related increase of prostate cancer …

The antioxidant effects of genistein are associated with AMP-activated protein kinase activation and PTEN induction in prostate cancer cells

CE Park, H Yun, EB Lee, BI Min, H Bae… - Journal of medicinal …, 2010 - liebertpub.com
Epidemiological evidence suggests a lower incidence of prostate cancer in Asian countries,
where soy products are more frequently consumed than in Western countries, indicating that …

Genistein, a soy isoflavone, induces glutathione peroxidase in the human prostate cancer cell lines LNCaP and PC‐3

K Suzuki, H Koike, H Matsui, Y Ono… - … journal of cancer, 2002 - Wiley Online Library
Genistein is a major component of soybean isoflavone and has multiple functions resulting
in antitumor effects. Prostate cancer is 1 of the targets for the preventive role of genistein. We …

[HTML][HTML] Plant flavone apigenin binds to nucleic acid bases and reduces oxidative DNA damage in prostate epithelial cells

H Sharma, R Kanwal, N Bhaskaran, S Gupta - PLoS One, 2014 - journals.plos.org
Oxidative stress has been linked to prostate carcinogenesis as human prostate tissue is
vulnerable to oxidative DNA damage. Apigenin, a dietary plant flavone, possesses anti …

Radiation‐induced HIF‐1α cell survival pathway is inhibited by soy isoflavones in prostate cancer cells

V Singh‐Gupta, H Zhang, S Banerjee… - … journal of cancer, 2009 - Wiley Online Library
We previously showed that treatment of prostate cancer cells with soy isoflavones and
radiation resulted in greater cell killing in vitro, and caused downregulation of NF‐κB and …

Genistein‐induced upregulation of p21 WAF1 , downregulation of cyclin B, and induction of apoptosis in prostate cancer cells

JN Davis, B Singh, M Bhuiyan, FH Sarkar - 1998 - Taylor & Francis
Increased soy consumption in Asian diets, resulting in increased serum isoflavone levels,
has been associated with a decreased risk for prostate adenocarcinoma (PCa). The …

Testosterone augments polyphenol‐induced DNA damage response in prostate cancer cell line, LNCaP

H Ide, J Yu, Y Lu, T China, T Kumamoto… - Cancer …, 2011 - Wiley Online Library
Recently, we reported that combined ingestion of soy isoflavones and curcumin significantly
decreased the serum level of prostate‐specific antigen based on a randomized placebo …

Genistein protects methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells

HJ Wu, WH Chan - Toxicology in Vitro, 2007 - Elsevier
Methylglyoxal (MG) is a reactive dicarbonyl compound produced mainly from glycolytic
intermediates in the cell and often found at high level in the blood from the diabetic patients …

Soy isoflavone supplementation in healthy men prevents NF-κB activation by TNF-α in blood lymphocytes

JN Davis, O Kucuk, Z Djuric, FH Sarkar - Free Radical Biology and …, 2001 - Elsevier
Dietary intake of soy has been associated with a decreased risk of cancer. Soy isoflavones
have been postulated to be the protective compounds in soybeans; however, the precise …

Antiproliferative effect of oleuropein in prostate cell lines

R Acquaviva, C Di Giacomo… - International …, 2012 - spandidos-publications.com
Currently, there is increasing interest in the in vivo protective effects of natural antioxidants
found in dietary plants against oxidative damage caused by free radical species. Oxidative …