Genistein protects prostate cells against hydrogen peroxide-induced DNA damage and induces expression of genes involved in the defence against oxidative stress
M Raschke, IR Rowland, PJ Magee… - …, 2006 - academic.oup.com
Prostate cancer is one of the most frequent cancer types in Western societies and
predominately occurs in the elderly male. The strong age-related increase of prostate cancer …
predominately occurs in the elderly male. The strong age-related increase of prostate cancer …
The antioxidant effects of genistein are associated with AMP-activated protein kinase activation and PTEN induction in prostate cancer cells
CE Park, H Yun, EB Lee, BI Min, H Bae… - Journal of medicinal …, 2010 - liebertpub.com
Epidemiological evidence suggests a lower incidence of prostate cancer in Asian countries,
where soy products are more frequently consumed than in Western countries, indicating that …
where soy products are more frequently consumed than in Western countries, indicating that …
Genistein, a soy isoflavone, induces glutathione peroxidase in the human prostate cancer cell lines LNCaP and PC‐3
K Suzuki, H Koike, H Matsui, Y Ono… - … journal of cancer, 2002 - Wiley Online Library
Genistein is a major component of soybean isoflavone and has multiple functions resulting
in antitumor effects. Prostate cancer is 1 of the targets for the preventive role of genistein. We …
in antitumor effects. Prostate cancer is 1 of the targets for the preventive role of genistein. We …
[HTML][HTML] Plant flavone apigenin binds to nucleic acid bases and reduces oxidative DNA damage in prostate epithelial cells
Oxidative stress has been linked to prostate carcinogenesis as human prostate tissue is
vulnerable to oxidative DNA damage. Apigenin, a dietary plant flavone, possesses anti …
vulnerable to oxidative DNA damage. Apigenin, a dietary plant flavone, possesses anti …
Radiation‐induced HIF‐1α cell survival pathway is inhibited by soy isoflavones in prostate cancer cells
V Singh‐Gupta, H Zhang, S Banerjee… - … journal of cancer, 2009 - Wiley Online Library
We previously showed that treatment of prostate cancer cells with soy isoflavones and
radiation resulted in greater cell killing in vitro, and caused downregulation of NF‐κB and …
radiation resulted in greater cell killing in vitro, and caused downregulation of NF‐κB and …
Genistein‐induced upregulation of p21 WAF1 , downregulation of cyclin B, and induction of apoptosis in prostate cancer cells
JN Davis, B Singh, M Bhuiyan, FH Sarkar - 1998 - Taylor & Francis
Increased soy consumption in Asian diets, resulting in increased serum isoflavone levels,
has been associated with a decreased risk for prostate adenocarcinoma (PCa). The …
has been associated with a decreased risk for prostate adenocarcinoma (PCa). The …
Testosterone augments polyphenol‐induced DNA damage response in prostate cancer cell line, LNCaP
H Ide, J Yu, Y Lu, T China, T Kumamoto… - Cancer …, 2011 - Wiley Online Library
Recently, we reported that combined ingestion of soy isoflavones and curcumin significantly
decreased the serum level of prostate‐specific antigen based on a randomized placebo …
decreased the serum level of prostate‐specific antigen based on a randomized placebo …
Genistein protects methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells
HJ Wu, WH Chan - Toxicology in Vitro, 2007 - Elsevier
Methylglyoxal (MG) is a reactive dicarbonyl compound produced mainly from glycolytic
intermediates in the cell and often found at high level in the blood from the diabetic patients …
intermediates in the cell and often found at high level in the blood from the diabetic patients …
Soy isoflavone supplementation in healthy men prevents NF-κB activation by TNF-α in blood lymphocytes
Dietary intake of soy has been associated with a decreased risk of cancer. Soy isoflavones
have been postulated to be the protective compounds in soybeans; however, the precise …
have been postulated to be the protective compounds in soybeans; however, the precise …
Antiproliferative effect of oleuropein in prostate cell lines
R Acquaviva, C Di Giacomo… - International …, 2012 - spandidos-publications.com
Currently, there is increasing interest in the in vivo protective effects of natural antioxidants
found in dietary plants against oxidative damage caused by free radical species. Oxidative …
found in dietary plants against oxidative damage caused by free radical species. Oxidative …