Background We have previously shown that small molecule PDGF receptor tyrosine kinase
inhibitors (RTKI) can drastically attenuate radiation-induced pulmonary fibrosis if the drug …

Purpose: Radiotherapy can induce the inflammatory response of alveolitis and the
excessive repair response of fibrosis through incompletely defined mechanisms. In previous …

Pulmonary fibrosis is the consequence of a variety of diseases with no satisfying treatment
option. Therapy-induced fibrosis also limits the efficacy of chemotherapy and radiotherapy in …

Background Several small receptor tyrosine kinase inhibitors (RTKI) have entered clinical
cancer trials alone and in combination with radiotherapy or chemotherapy. The inhibitory …

Background: Radiotherapy (RT) is a mainstay for the treatment of lung cancer, but the
effective dose is often limited by the development of radiation-induced pneumonitis and …

Purpose: Radiotherapy is used for the treatment of lung cancer, but at the same time induces
acute pneumonitis and subsequent pulmonary fibrosis, where TGF-β signaling is considered …

Background Nintedanib has anti-fibrotic and anti-inflammatory activity and is approved for
the treatment of idiopathic pulmonary fibrosis. The aim of this study was to noninvasively …

Radiation-induced complications of the respiratory system are a common side effect of
thoracic radiotherapy with no viable treatment option. Here, we investigated the potential …

Imatinib mesylate is a potent and specific tyrosine kinase inhibitor against c-ABL, BCR-ABL,
and c-KIT, and has been demonstrated to be highly active in chronic myeloid leukemia and …

Purpose Ionizing radiation (IR)–induced pulmonary fibrosis (PF) is an irreversible and
severe late effect of thoracic radiation therapy. The goal of this study was to determine …